Brain imaging studies on neural basis of self reference in depression

抑郁症自我参照神经基础的脑成像研究

• 批准号: 21591518
• 负责人: OKAMOTO Yasumasa
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591518/
• 关键词: 自己; 認知; 情動; うつ病; fMRI; 自己認知; 認知行動療法; 内側前頭前野; 前帯状回

Depression is characterized by enhanced self-referential processing of negative emotional stimuli. Imaging studies have suggested that activation of both the medial prefrontal(MPFC) and anterior cingulate cortices(ACC) is associated with self-referential processing. However, whether this pattern of activation occurs in depressed individuals during the self-referential processing of the emotional stimuli had not been investigated to date. Thus, we have studied some experiments and got some following results. Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the ACC during the self-referential processing of negative words. Activity in the MPFC and the ACC during self-referential processing of negative stimuli were decreased in the depressive patients following CBT. These results showed that improvement of depressive symptoms was associated with attenuation of the MPFC and the ACC activation during self-referential processing of negative emotion.

抑郁症的特点是对负面情绪刺激的自我参照处理增强。影像学研究表明，内侧前额叶（MPFC）和前扣带皮层（ACC）的激活与自我参照处理有关。然而，迄今为止，尚未研究过这种激活模式是否发生在抑郁个体在情绪刺激的自我参照处理过程中。因此，我们进行了一些实验研究并得到了一些结果。与正常对照组相比，抑郁症患者在消极词语的自我参照处理过程中，MPFC 和 ACC 表现出过度活跃。 CBT 后抑郁症患者在消极刺激的自我参照处理过程中 MPFC 和 ACC 的活动有所下降。这些结果表明，抑郁症状的改善与消极情绪自我参照处理过程中 MPFC 和 ACC 激活的减弱有关。

项目成果

Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity.

• DOI: 10.1016/j.jad.2009.06.017
• 发表时间: 2010-04
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Shinpei Yoshimura;Y. Okamoto;K. Onoda;M. Matsunaga;K. Ueda;Shin-ichi Suzuki;Shigetoyamawaki

精神療法における認知・行動・情動の脳内基盤

心理治疗中认知、行为和情感的大脑基础

• 发表时间: 2011
• 期刊: うつ病の認知行動療法を一例として
• 作者: Keiko Nomura;Hiroaki Kazui;Yumiko Kito;Tamiki Wada;Hiromichi Sugiyama;Daisuke Yamamoto;Kenji Yoshiyama;Hiromasa Tokunaga;Eku Shimosegawa;Jun Hatazawa;Masatoshi Takeda;岡本泰昌ほか
• 通讯作者: 岡本泰昌ほか

精神療法における認知・行動・情動の脳内基盤-うつ病の認知行動療法を一例として-

心理治疗中认知、行为和情感的大脑基础 - 以抑郁症的认知行为疗法为例 -

• 发表时间: 2011
• 期刊: 精神神経学雑誌
• 作者: 岡本泰昌;ほか
• 通讯作者: ほか

うつ病の集団認知行動療法実践マニュアル:復職支援と再発予防に向けて

抑郁症团体认知行为治疗实用手册：重返工作支持和预防复发

• 发表时间: 2011
• 作者: 鈴木伸一;岡本泰昌;松永美希編
• 通讯作者: 松永美希編