Functional and morphological integrated assessments of hepato-biliary-pancreatic carcinomas using 320 detector-row CT

使用 320 排 CT 对肝胆胰癌进行功能和形态学综合评估

• 批准号: 21591563
• 负责人: YOSHIKAWA Takeshi
• 金额: $ 3.24万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591563/
• 关键词: 領域検出器型CT; 上腹部; 臓器血流・機能測定; 臓器血流測定ソフトウエア; 低X線量CT撮影; 形態・機能融合診断法

We evaluated newly-developed Area-Detector CT in functional and morphological assessments of the upper abdominal organ function and diseases. Area-Detector CT was superior to conventional CT in assessment of fine abdominal vessels. We developed CT scanning protocol and injection protocol of contrast medium for abdominal functional(perfusion) CT, correction software for respiratory misregistrations, and software for perfusion analysis with three different analytic methods. Our results showed irradiation during perfusion CT can be reduced to 1/3 and volume and injection rate of contrast medium can be reduced to 1/3 of those in the conventional methods and respiratory misregistrations less than 3 cm can be satisfactorily corrected. Effects of cardiac function were found and it needs to be compensated. In patients with abdominal diseases, we found new findings such as interactions in blood perfusion among the organs and useful perfusion parameters for diagnosis for malignant tumors. It was also found that perfusion CT is useful for assessment of tumor responses after radiotherapy and anticancer agents as well as residual organ function. The results of this study suggest functional and morphological integrated CT using Area-Detector CT can be superior to those of conventional morphological CT in assessments of the upper abdominal organ function and diseases.

我们评估了新开发的区域探测器 CT 对上腹部器官功能和疾病的功能和形态学评估。区域探测器 CT 在评估腹部细血管方面优于传统 CT。我们开发了腹部功能（灌注）CT 的 CT 扫描方案和造影剂注射方案、呼吸重合失调校正软件以及采用三种不同分析方法的灌注分析软件。我们的结果表明，灌注CT时的照射量可减少至常规方法的1/3，对比剂的体积和注射速度可减少至常规方法的1/3，并且可以令人满意地纠正小于3厘米的呼吸重合失调。发现了心脏功能的影响，需要对其进行补偿。在患有腹部疾病的患者中，我们发现了新的发现，例如器官之间血液灌注的相互作用以及用于诊断恶性肿瘤的有用灌注参数。研究还发现，灌注 CT 可用于评估放疗和抗癌药物后的肿瘤反应以及残余器官功能。本研究的结果表明，使用区域探测器 CT 的功能和形态学综合 CT 在评估上腹部器官功能和疾病方面优于传统形态学 CT。

项目成果

Capability of abdominal 320-detector row CT for small vasculature assessment compared with that of 64-detector row CT

腹部 320 排 CT 与 64 排 CT 评估小血管系统的能力比较

• 发表时间: 2011
• 期刊: Eur J Radiol
• 影响因子: 3.3
• 作者: Kitajima K;Maeda T;Ohno Y;Yoshikawa T;Konishi M;Kanda T;Onishi Y;Matsumoto K;Koyama H;Takenaka D;Sugimura K
• 通讯作者: Sugimura K

上腹部CT perfusion :造影剤濃度が解析法に及ぼす影響の検討

上腹部CT灌注：检查造影剂浓度对分析方法的影响

• 发表时间: 2012
• 作者: 神田知紀;吉川武;大野良治;藤澤恭子;金田直樹;小西稔;神山久信;北島一宏;竹中大祐;杉村和朗
• 通讯作者: 杉村和朗

Whole Upper Abdominal CT Perfusion Measurements : Effects of Contrast Medium Iodine Concentration on the Values Estimated by Three Analytic Methods

全上腹部 CT 灌注测量：造影剂碘浓度对三种分析方法估计值的影响

• 发表时间: 2011
• 作者: Kanda T;Yoshikawa T;Ohno Y;Fujisawa Y;Murakami T;Koyama S;Kanata N;Takenaka D;Koyama H;Kitajima K;Sugimura K
• 通讯作者: Sugimura K

Optimization of Contrast Medium Administration in Whole Upper Abdominal CT Perfusion Measurements with 320-Detector Row CT

320 排 CT 整个上腹部 CT 灌注测量中造影剂给药的优化

• 发表时间: 2011
• 作者: Yoshikawa T;Kanda T;Ohno Y;Konishi M;Kanata N;Koyama H;Takenaka D;Kitajima K;Sugimura K
• 通讯作者: Sugimura K

20列CTを用いた上腹部CT Perfusion:臓器血流量の肝疾患群・非疾患群および各種治療前後の比較

20排CT上腹部CT灌注：肝病组、非疾病组、各种治疗前后器官血流比较

• 发表时间: 2011
• 作者: 神田知紀;吉川武;大野良治;小西稔;山口雅人;金田直樹;神山久信;竹中大祐;北島一宏;杉村和朗
• 通讯作者: 杉村和朗