Association between risk and prognostic values of breast cancer and the wild-type allele of human ABC transporter ABCC11.

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It was found that earwax type is determined by a single nucleotide polymorphism in ABCC11.The present study examined the association between the frequency rate of breast cancer and the polymorphism(G allele) of ABCC11.The frequency of the G allele in breast cancer patients was higher than that in healthy controls in Japan. The odds ratio for the genotypes to develop breast cancer was estimated to be 1.63(p-value=0.026), suggesting that the G allele in ABCC11 is associated with breast cancer risk. This study showed that Japanese women with wet earwax have a higher relative risk of developing breast cancer than those with dry earwax.