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The elucidation of mechanisms for Collagen Type Vα3 chains anti-organ adhesion function and there application.

The elucidation of mechanisms for Collagen Type Vα3 chains anti-organ adhesion function and there application.
Vα3型胶原蛋白链抗器官粘连功能机制的阐明及其应用。
批准号:
21591672
负责人:
SUMIYOSHI Hideaki
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Organ adhesion were one case of excess tissue fibrosis caused wound healing after operation. Organ adhesion has bad influences for functional recovery and patients QOL. In this study elucidated that, minor component of collagen Type Vα3 chain(α3(V)) has anti tissue adhesion and fibrosis activity and specific expression in early time wound tissue. Inα3(V) rich regions collagen fiber observed thin and soft shapes. The idea forα3(V) anti-fibrosis activity were inhibited collagen banding step directly for any data from this study.α3(V) could very promising material for organ adhesion blocking treatment.
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Sp7/Osterix is involved in the up-regulation of the mouse pro-alpha 1(V) collagen gene(Col5a1) in osteoblastic cells
Sp7/Osterix 参与成骨细胞中小鼠 pro-alpha 1(V) 胶原蛋白基因 (Col5a1) 的上调
DOI: --
发表时间: 2010
期刊: Matrix Biology
影响因子: 6.9
作者: [Wu Y., Matsuo N. Sumiyoshi H. and Yoshioka H.]
通讯作者: Matsuo N. Sumiyoshi H. and Yoshioka H.
骨髄細胞由来の肝線維化改善・再生因子の同定と臨床応用
骨髓细胞源性肝纤维化改善/再生因子的鉴定及临床应用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [福光寛, 東山礼一, 中尾祥絵, 皆川香織, 茂呂忠, 三上健一郎, 住吉秀明, 山岡華児, 東清史, 稲垣豊]
通讯作者: 稲垣豊
The study of fibrogenesis using a wound healing model
使用伤口愈合模型研究纤维发生
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [住吉秀明, 松尾哲孝, 吉岡秀克]
通讯作者: 吉岡秀克
DOI: 10.1021/bi901066f
发表时间: 2010-01-12
期刊: BIOCHEMISTRY
影响因子: 2.9
作者: [Okamoto, Osamu, Hozumi, Kentaro, Fujiwara, Sakuhei]
通讯作者: Fujiwara, Sakuhei
16
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