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Effect of DNA methylation on the regulation of microRNA in squamous cell carcinoma of the esophagus

Effect of DNA methylation on the regulation of microRNA in squamous cell carcinoma of the esophagus
DNA甲基化对食管鳞癌microRNA调控的影响
批准号：
21591704
负责人：
WATANABE Masayuki
金额：
$2.91万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591704/
关键词：
DNAメチル化異常SYBR green法microRNAホルマリン固定標本化学療法感受性食道癌食道扁平上皮癌micoRNApyrosequenceLINE-1FBXW7ZEB-2

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英文摘要
We clarified that global hypomethylation was observed in squamous cell carcinoma of the esophagus(ESCC) and the hypomethylation of LINE-1 was a significant indicator for poor prognosis in patients with ESCC. We also identified that overexpression of microRNA(miR)-29c was a prognostic factor of patients with ESCC and miR-223 regulated FBXW7 in ESCC. We examined miR-21 expression in the serum and clarified that the serum miR-21 levels of ESCC patients was significantly higher than those of healthy controls and the serum miR-21 expression could be a marker for treatment effect for ESCC.
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会议论文
Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma
DOI： 10.1002/jso.23064
发表时间： 2012-08-01
期刊： JOURNAL OF SURGICAL ONCOLOGY
影响因子： 2.5
作者： [Kurashige, Junji, Kamohara, Hidenobu, Baba, Hideo]
通讯作者： Baba, Hideo
胃癌におけるmicroRNA-200bによる癌浸潤転移の制御機構 / The miR-200b regulates epithelial to mesenchymal transition in gastric cancer
miR-200b 调节胃癌上皮间质转化
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Kinoshita H, Okabe H, Beppu T, Chikamoto A, Hayashi H, Imai K, Mima K, Nakagawa S, Yokoyama N, Ishiko T, Shinriki S, Jono H, Ando Y, Baba H., 蔵重淳二]
通讯作者： 蔵重淳二
LINE-1 Hypomethylation Is Associated With a Poor Prognosis Among Patients With Curatively Resected Esophageal Squamous Cell Carcinoma
DOI： 10.1097/sla.0b013e31826d8602
发表时间： 2013-03-01
期刊： ANNALS OF SURGERY
影响因子： 9
作者： [Iwagami, Shiro, Baba, Yoshifumi, Baba, Hideo]
通讯作者： Baba, Hideo
MicroRNA-21 regulates proliferation and invasion in esophagus squamous cell carcinoma
MicroRNA-21调节食管鳞状细胞癌的增殖和侵袭
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Kitamura A, Matsushita K, Takiguchi Y, Shimada Hideaki, Tomonaga T, Matsubara H.Inou, M, Mamoru H, Sato Y, Levens D, Tatsumi K, Nomura F., 日吉幸晴]
通讯作者： 日吉幸晴
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