The effect of suppression of NF kB activity on the radio-sensitivity of colon cancer cells and on the prevention of intestinal damage.
The effect of suppression of NF kB activity on the radio-sensitivity of colon cancer cells and on the prevention of intestinal damage.
批准号:
21591738
负责人:
YOSHIDA Yasuhiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In a mouse model of radiation induced-chronic intestinal injury, fibrogenesis was seen in the submucosal layer. We investigated the effect of HGF administration and NF-kB decoy transfection on fibrogenesis of intestinal wall in a mouse model. HGF administration, but not NF-kB decoy transfection, inhibited the fibrogenesis in the intestinal wall. Next, we investigated the effect of low-dose HGF administration and NF-kB decoy transfection on proliferation ability of a cell line of human colon cancer. NF-kB decoy transfection, but not low-dose HGF administration, inhibited proliferation of cancer cells. Last, we investigated the relationship between NF-kB and EMT in cancer cells. Unfortunately, NF-kB transfection did not change the gene expression of EMT related molecules.
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Impact of preoperative 3D hepatectomy simulation system for liver resection and transplantation : Application to various kind of liver resection procedure
术前3D肝切除模拟系统对肝切除和移植的影响:在各种肝切除手术中的应用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fujimoto J, Iimuro Y, Yada A, Kondo Y, Saito S, Sueoka H, Ohashi K.]
通讯作者:
Ohashi K.
DOI:
10.1111/j.1872-034x.2011.00822.x
发表时间:
2011-07
期刊:
Hepatology research : the official journal of the Japan Society of Hepatology
影响因子:
--
作者:
[Seki E, Park E, Fujimoto J]
通讯作者:
Fujimoto J
肝細胞癌内線維化領域に存在する線維芽細胞の免疫組織学的検討
肝细胞癌纤维化区域中成纤维细胞的免疫组织学检查
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Iimuro Y, Kashiwagi T, Yamanaka J, Hirano T, Saito S, Sugimoto T, Watanabe S, Kuroda N, Okada T, Asano Y, Uyama N, Fujimoto J, 鈴村和大,森川司朗,岡田敏弘,王孔志,黒田暢一,平野公通,宇山直樹,佐竹真,藤元治朗, 宇山直樹,波多野悦朗,前谷洋爾,磯田裕義,柴田登志也,田浦康二郎,大江正士郎,内藤雅人,安近健太郎,藤井英明,猪飼伊和夫,上本伸二, 宇山直樹, 宇山直樹,飯室勇二,中井紀博,近藤祐一,鈴村和大,佐竹真,吉田康彦,杉本貴昭,麻野泰包,斉藤慎一,王孔志,岡田敏弘,平野公通,黒田暢一,山中潤一,藤元治朗]
通讯作者:
宇山直樹,飯室勇二,中井紀博,近藤祐一,鈴村和大,佐竹真,吉田康彦,杉本貴昭,麻野泰包,斉藤慎一,王孔志,岡田敏弘,平野公通,黒田暢一,山中潤一,藤元治朗
In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice
伊马替尼对外显子 17 型 c-kit 敲入小鼠盲肠 GIST 样肿瘤进展的体内影响
DOI:
--
发表时间:
2009
期刊:
Lab Invest 89
影响因子:
--
作者:
[K amo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwaraa Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N., Nishida T, Kamo N, Ishikawa T]
通讯作者:
Ishikawa T
Application of computational portal flow dynamics simulation to liver regeneration analysis
计算门静脉血流动力学模拟在肝再生分析中的应用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Iimuro Y, Uyama N, Sugimoto T, Saito S, Hirano T, Yamanaka J, Fujimoto J.]
通讯作者:
Fujimoto J.
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Reconsidering the position of Charles Lamb among the Romantic writers
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批准号:25580061
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$1.41万
-
财政年份:2013
-
负责人:YOSHIDA Yasuhiko
-
依托单位:
Graft polymerization of PHA to Chitin/Chitosan
-
批准号:11217213
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$10.3万
-
财政年份:1999
-
负责人:YOSHIDA Yasuhiko
-
依托单位:
海外基金