Identification of novel brain tumor stem cell markers and development of molecular targeting therapies for malignant gliomas

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In this study, we showed that CD166/ activated leukocyte cell adhesion molecule(ALCAM) was highly expressed on glioblastoma progenitor cells. ALCAM^+ CD133^+ cells were highly enriched with tumor-sphere-initiating cells in vitro. The investigation about the in vitro and in vivo function of ALCAM in glioblastoma cells demonstrated ALCAM and its soluble isoform may be involved in invasion, progression and angiogenesis in glioblastomas and can result in poor prognosis or resistance against chemo-radiotherapies. Development of molecular targeting therapy against souble ALCAM should be planned in the future.