Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins

我们以前报道过，超过60%的滑膜间充质干细胞（MSCs）放置在骨软骨缺损处，在10分钟内粘附到缺损处，并促进软骨再生。在这项研究中，我们研究了镁是否通过整合素增强滑膜MSC的粘附和软骨形成。在滑膜间充质干细胞体外软骨形成过程中，镁可增加人滑膜间充质干细胞与胶原的粘附，促进软骨基质的合成。在兔体内的研究表明，镁促进粘附在1天和软骨形成的滑膜MCS在2和4周。镁可促进滑膜间充质干细胞的粘附，并促进软骨基质的早期合成。

We previously reported that more than 60% of synovial mesenchymal stem cells(MSCs) placed on osteochondral defects adhered to the defect within 10 minutes and promoted cartilage regeneration. In this study, we investigated whether magnesium enhanced adherence and chondrogenesis of synovial MSC through integrins. Magnesium increased adhesion of human synovial MSCs to collagen and promoted synthesis of cartilage matrix during in vitro chondrogenesis of synovial MSCs. In vivo studies in rabbits showed that magnesium promoted adherence at 1 day and cartilage formation of synovial MCSs at 2 and 4 weeks. Magnesium enhanced adherence of synovial MSCs and promoted synthesis of cartilage matrix at an early phase.