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Regenerative repair of bone defeots with osteoinduotive hydroxyapatite fabr icated to match the defect and implanted with combined use of computer-aided design, computer-aided manufaoturing, and computer-assisted surgery systems : a feasibility study in a

结合使用计算机辅助设计、计算机辅助制造和计算机辅助手术系统，用骨诱导羟基磷灰石制造以匹配缺损并植入的骨缺损的再生修复：一项可行性研究

基本信息

批准号：
21591922
负责人：
IWAKI Hiroyoshi
金额：
$ 2.75万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Currently, regenerative repair of large bone detect is a challenging issue. The aim of this study was to achieve repair of large bone defects to the original three-dimensional(3D) anatomical state. An imaginary spherical malignant bone tumor of was placed in the left ilium of a canine on the 3D imaue. Resection of the whole tumor was planned preoperatively by using computer-aided design software. An image of the implant to fill the resulting bone defect was constructed on the computer image. A porous hydroxyapatite implant identical to the imaged bone defect was made with a computer-aided manufacturing system. To resect the iliac bone as planned preoperatively on the 3^CT image, computer-aided surgery was performed. The defect was filled with the fabricated implant and coated with a putty carrier with BMP-2.New bone formation was noted around each implant on CT images and remodeled to restore the original anatomy of the ilium on serial CT images. This new method may enable efficacious and precise regenerative repair of large bone defect without bone grafting.

目前，大骨缺损的再生修复是一个具有挑战性的课题。本研究的目的是实现大面积骨缺损修复到原始三维（3D）解剖状态。在3D图像上，将一个假想的球形恶性骨肿瘤放置在一只犬的左髂骨中。术前使用计算机辅助设计软件计划全肿瘤切除。在计算机图像上构建用于填充所产生的骨缺损的植入物的图像。用计算机辅助制造系统制造与成像的骨缺损相同的多孔羟基磷灰石植入物。为了按照术前计划在3^CT图像上切除髂骨，进行了计算机辅助手术。CT扫描显示种植体周围有新骨形成，连续CT扫描显示种植体周围有新骨形成，重建后的髂骨恢复了原有的解剖结构。这种新的方法可以实现有效和精确的再生修复大骨缺损，而无需植骨。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Saeittal alignment of the lower extremity while standing in female.

女性站立时下肢的 Saeital 对齐。

DOI：
发表时间：
2011
期刊：
Knee Surg Sports T raumatol Arthrosc.
影响因子：
0
作者：
Sugarna R;Minoda Y. Kobayashi A;Iwaki H;Ikebuchi M;Hashimoto Y;Takaoka K;Nakamura H.
通讯作者：
Nakamura H.

Regenerative repair of bone defect with osteoinductive hydroxyapatite fabricated to match the defect and implanted with combined use of computer-aided design, computer-aided manufacturing, and computer-assisted surgery systems-A feasibility study in a can

结合计算机辅助设计、计算机辅助制造和计算机辅助手术系统，用骨诱导羟基磷灰石制造匹配缺损并植入的骨缺损再生修复-罐头可行性研究