Identification of osteoblast function regulating factor secreted by human mesenchymal stem cell

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We investigated whether cell death is induced during the calcification process by osteoblast derived from human bone marrow mesenchymal stem cells in vitro, and whether dead cells are involved in the calcification process. Our findings showed that cell death was induced in osteogenic culture of mesenchymal stem cells in vitro, and suggested that caspase-independent dead cells and/or necrotic dead cells of osteoblast lineage might be involved in the mechanism of bone calcification.