Isoflurane-induced postconditioning is mediated by activation of mitochondrial calcium-activated potassium channels

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Volatile anesthetics isoflurane have an anesthetic postconditioning effects that induce cardioprotective effects against myocardial ischemia and reperfusion injury. We demonstrated that activation of mitochondrial calcium-activated potassium channels play a pivotal role on these action. Furthermore, we showed that volatile anesthetics induced modulation of mitochondrial protein by O-linked beta-N-acetylglucosamine also have an important for volatile anesthetics induced cardioprotection.