Role of endogenous prostanoids in vascular remodeling

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The intimal areas and medial areas two weeks after ligation of left common carotid arteries increased in both wild-type (WT) and EP4 receptor knockout (EP4^<-/->) mice. The intimal area four weeks after ligation was significantly increased in the ligated WT arteries compared with EP4^<-/-> arteries. I/M ratio and stenotic ration four weeks after blood flow cessation were also significantly increased in the ligated WT arteries compared with EP4^<-/->arteries. These results indicate that endogenous PGE2 plays an important role in intimal hyperplasia caused by blood-flow cessation via EP4 receptor.