Bran-New Indicator of the Management for Living Donor Liver Transplantation : Exhaled Carbon Monoxide

在活体肝移植过程中，缺血/再灌注后会发生一些变化。如今，这些变化没有明确的指标。因此，我们研究了呼出的一氧化碳（CO）浓度是否可以作为肝移植期间这些变化的指标。结果发现，呼出的CO浓度与肝内血红素加氧酶-1基因表达和蛋白表达也有相关性。提示呼出一氧化碳浓度可作为缺血/再灌注损伤的一种新的治疗指标。

During living donor liver transplantation, several changes would be happen after ishcemia/reperfusion. Nowadyas, there is no definite indicator of these changes. Therefore, we examined whether exhaled carbon monoxide(CO) concentration would be the indicator of these changes during liver transplantation. As the results, we found that exhaled CO concentration had a correlation with intra-hepatic heme oxygenase-1 gene expression and protein expression as well. This result indicated that exhaled CO concentration would be a novel therapeutic marker of ishcemia/reperfusion injury.