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Exploration of a new molecular target of hormone refractory prostate cancer based on nuclear matrix proteins

Exploration of a new molecular target of hormone refractory prostate cancer based on nuclear matrix proteins
基于核基质蛋白的激素难治性前列腺癌新分子靶点探索
批准号:
21592043
负责人:
INOUE Takahiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The aim of this research is to analyze whether a nuclear matrix protein, Purine-element binding protein alpha(PURA), is useful for exploration for a new molecular target of hormone refractory prostate cancer.Overexpression of PURA obviously lowered the growth speed of PC3 cells in vivo, and by immunohistochemistry, Ki67 expression was weaker in PC3 cells with PURA overexpression than in control PC3 cells. And we have established tissue microarray, including 22 cases of castration resistant prostate cancer, which were obtained by TUR. Using this microarray, we are planning to ask how those expression changes with progression of prostate cancer.
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アンドロゲン非依存性進展に伴うシグナル伝達異常
与雄激素独立性发展相关的信号转导异常
DOI: --
发表时间: 2011
期刊: 日本臨床増刊号前立腺癌(第二版)
影响因子: --
作者: [今村哲也, 石井健一朗, 荒瀬栄樹, 吉尾裕子, 堀靖英, 曽我倫久人, 木瀬英明, 有馬公伸, 杉村芳樹, 井上貴博]
通讯作者: 井上貴博
日本人における前立腺癌のゲノムワイド関連解析のフォローアップスタディーにより新たに4つの前立腺癌罹患関連領域が同定された
日本人前列腺癌全基因组关联分析的后续研究确定了与前列腺癌发病率相关的四个新区域。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Akamateu S, Takata R, Kamatani N, Fujioka T, Ogawa O, Kubo M, Nakamura Y, Nakagawa H., 赤松秀輔, 赤松秀輔, 赤松秀輔, 赤松秀輔, 赤松秀輔, 赤松秀輔, 赤松秀輔, 赤松秀輔]
通讯作者: 赤松秀輔
活性型FAK (Focal adhesion kinase)の発現は前立腺がん全摘後の生化学的再発と相関する
激活的 FAK(粘着斑激酶)的表达与全前列腺癌切除后的生化复发相关
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [井上貴博, 小林恭, 前野淳, 赤松秀輔, 岡田能幸, 吉川武志, 清水洋祐, 神波大己, 小川修]
通讯作者: 小川修
DOI: 10.1007/s10147-011-0326-z
发表时间: 2011
期刊: Int J Clin Oncol.
影响因子: --
作者: [Mizowaki T, Takayama K, Norihisa Y, Ogura M, Kamba T, Inoue T, Shimizu Y, Kamoto T, Ogawa O, Hiraoka M]
通讯作者: Hiraoka M
9
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    • 资助金额:
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