Identification and translational research of transmenbrane and secretary proteins in prostate cancer

我们从大肠杆菌氨苄西林分泌陷阱(CAST)文库中筛选出编码前列腺癌中存在的跨膜蛋白的候选基因。进一步的研究发现CDON和NBL1在PCa中的表达要高得多，这表明这些分子有很高的潜力作为PCa的治疗靶点。此外，我们认为DSC2是分离尿路上皮癌鳞状分化的一个有用的免疫组织化学标记物。

We identified candidate genes that encode transmembrane proteins present in PCa from the screening of Escherichia coli ampicillin secretion trap(CAST) libraries. Further investigations reveled that CDON and NBL1 were expressed much more highly in PCa, suggesting that these molecules have a high potential as a therapeutic target for PCa. Furthermore, we conclude that DSC2 is a useful immunohistochemical marker for separation of squamous differentiation of urothelial carcinoma.