Basic study of High-intensity focused ultrasound for fetal therapy

本课题开展了高强度聚焦超声在胎儿治疗中应用的动物模型和体模实验的基础研究。本研究调查了HIFU的最佳强度和超声频率、暴露时间、动脉闭塞的有效性和安全性，得出结论：我们可以将HIFU应用于人类胎儿。临床研究伦理委员会批准了该程序，并在充分解释后获得了患者的同意。虽然在这种情况下，该过程并不完全成功，但首次证明了诱导人类胎儿组织局部变性的可能性，从而标志着未来在胎儿治疗中使用HIFU的一步。

We conducted basic research on animal models and phantom experiment, which involved the application of HIFU to fetal treatment. This study, which investigated the optimum intensity and ultrasound frequency of HIFU, exposure time, effectiveness for arterial occlusion, and safety, led to the conclusion that we can apply HIFU to human fetuses. The Ethics Committee for Clinical Studies approved the procedure and consent was obtained from the patient after a full explanation. Although the procedure was not completely successful in this case, the possibility of inducing localized denaturation of human fetal tissue has been demonstrated for the first time, thus marking a step toward the future use of HIFU in fetal treatment.