The Relationship between Aging and Heat Shock Response in the Inner Ear
The Relationship between Aging and Heat Shock Response in the Inner Ear
批准号:
21592157
负责人:
YAMASHITA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Mechanisms of age-related hearing loss have not been elucidated as aging processes are extremely complex. We examined age-related expression of HSPs in the cochlea of animal model of age-related hearing loss. The results showed that the mice showed weakening expression of Hsp70 and Hsp110 with age. In addition, we showed that hearing loss deteriorated in HSF1 null mice. These results demonstrate that the heat shock responses have a grate role in the age-related hearing loss
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Relation between formation of aggregations and upregulation of heart shock protein in animal models
动物模型中聚集体形成与心休克蛋白上调之间的关系
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[中本, 御厨, ら, 御厨剛史, 御厨剛史, Mikuriya]
通讯作者:
Mikuriya
加齢における内耳熱ショック蛋白質発現の変化
衰老过程中内耳热休克蛋白表达的变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[広瀬敬信, 菅原一真, 御厨剛史, 中本哲也, 橋本誠, 下郡博明,山下裕司]
通讯作者:
下郡博明,山下裕司
SSSR、FGLMNH2による有毛細胞保護効果について
关于SSSR和FGLMNH2的毛细胞保护作用
DOI:
--
发表时间:
2011
期刊:
頭頸部自律神経
影响因子:
--
作者:
[吉田周平, 菅原一真, 豊田英樹, 金川英寿, 下郡博明, 山下裕司]
通讯作者:
山下裕司
Makoto Hashimoto, Takuo Ikeda, Kazuma Sugahara, Hironori Fujii, Hiroaki Shimogori, Hiroshi Yamashita : Analysis of the Eye Movement by Original Video-Oculography, HI-VOG
Makoto Hashimoto、Takuo Ikeda、Kazuma Sugahara、Hironori Fujii、Hiroaki Shimogori、Hiroshi Yamashita:通过原始视频眼图分析眼球运动,HI-VOG
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Makoto Hashimoto, Takuo Ikeda, Kazuma Sugahara, Hironori Fujii, Hiroaki Shimogori, Hiroshi Yamashita]
通讯作者:
Hiroshi Yamashita
Quantiative Analysis of Nystagmus by Image Analysis Technique
图像分析技术对眼球震颤的定量分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Makoto Hashimoto, Kazuma Sugahara, Ikeda Takuo, Hiroaki Shimogori, Hiroshi Yamashita]
通讯作者:
Hiroshi Yamashita
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The protection with heat shock response in the inner ear
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