The protection with heat shock response in the inner ear
The protection with heat shock response in the inner ear
批准号:
19591973
负责人:
YAMASHITA Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
本研究は, 感覚細胞死を抑制する保護療法を目的として行われた。熱ショック応答という生体に備わる保護機構を利用することから, 副作用が軽微である点, よって長期にわたって治療が可能な点が長所として期待される。内耳における熱ショック応答の役割を充分に明らかにできれば, 将来的に内耳保護療法として臨床に応用できる可能性が高いと考えられる。加齢による進行性難聴モデルマウスを用いて, 熱ショック応答誘導剤が難聴の進行を抑制できることを明らかにし論文化した。また, 加齢によって, 内耳における熱ショック応答が減弱し, 強大音などのストレスに対する耐性が低下することを明らかにしたた。
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The Expression of Heat Shock Proteins in the Cochlea of DBA/2J Mice
DBA/2J小鼠耳蜗热激蛋白的表达
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kazuma Sugahara, Takefumi Mikuriya, Yoshinobu Hirose, Yuji Miyauchi, Makoto Hashimoto, Hiroaki Shimogori, Hiroshi Yamashita]
通讯作者:
Hiroshi Yamashita
熱ショック応答誘導剤による内耳熱ショック応答の修飾と音響ストレスとの関係
热休克反应诱导器对内耳热休克反应的修正及其与声应力的关系
DOI:
--
发表时间:
2008
期刊:
頭頸部自律神経 22
影响因子:
--
作者:
[御厨剛史, 菅原一真, 広瀬敬信, 竹本剛, 橋本 誠, 下郡博明, 山下裕司]
通讯作者:
山下裕司
有毛細胞死におけるミトコンドリアの役割
线粒体在毛细胞死亡中的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[宮内裕爾, 菅原一真, 橋本誠, 新井紹之, 下郡博明, 山下裕司]
通讯作者:
山下裕司
DBA/2Jマウスでの熱ショック応答増強・維持による進行性難聴の保護の試み
尝试通过增强和维持 DBA/2J 小鼠的热休克反应来保护进行性听力损失
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[御厨剛史, 菅原一真, 広瀬敬信, 橋本誠, 下郡博明, 山下裕司]
通讯作者:
山下裕司
進行性難聴モデルにおける蝸牛内熱ショック蛋白質発現の変化と保護の検討
进行性听力损失模型中耳蜗热休克蛋白表达和保护的变化检查
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[御厨剛史, 菅原一真, 山下裕司]
通讯作者:
山下裕司
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Modern study on homogeneous spaces and unitary representations via duality
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Effect of Flame Surface Shape and Unsteady Behavior on Flame Structure of Turbulent Premixed Flames
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Expansion of Buddhism and Hinduism toward Southeast Asia and the Problem of Kingship : with special reference to the epics and the classical codes
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Historical Development of the Bhakti Movement in Medieval Hinduism
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