Functional analysis of candidate tumor suppressor gene, ING family in head and neck squamous cell carcinoma.

点击翻译按钮获取中文摘要

In the present research project, we investigated the function of candidate tumor suppressor gene, ING family in oral squamous cell carcinoma(OSCC). LOH analysis of ING2 gene revealed that allelic loss of ING2 gene was frequent in the patients with late stage(T3-4), suggesting tumor suppressive role of ING2 in OSCC. Mutation analysis for ING5 gene implied that decreased expression of ING5 mRNA or mutation might be the cause of loss of tumor suppressive function of ING5. Moreover, concerted function of ING family members was also suggested and allelic loss of ING family was also common in benign tumor. All the results obtained are of value as a basic study to establish a gene targeted therapy in OSCC treatment.