Development of oral disease by inhibition of nuclear transport of Aire

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Dexamethasone(Dex) induced trans-location of AIRE protein from nucleus to cytoplasm, and reduced expression of Aire, CD80 and Ins1 mRNA in thyms epithelial cells(TEC) of Fatal Thymus Organ culture(FTOC). The trans-location and reduced expression of these mRNAs were detected neither in mouse TEC culture system nor mouse thymus in vivo. These results indicated that translocation of nuclear Aire to cytoplasm inhibit differentiation of TEC, although the phenomenon were specific event in TEC of FTOC. In Sjogren' s syndrome(SS) mouse model, expression of Aire mRNA was totally reduced, however, the expression intensity depends on each lymph node. This result suggested that reduction of AIRE associated with mouse SS developing mechanism.