Development of oral disease by inhibition of nuclear transport of Aire

抑制艾尔核转运导致口腔疾病的发生

• 批准号: 21592392
• 负责人: SHIBATA Yasuaki
• 金额: $ 2.83万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592392/
• 关键词: 胸腺; AIRE; デキサメタゾン; 胸腺上皮細胞

Dexamethasone(Dex) induced trans-location of AIRE protein from nucleus to cytoplasm, and reduced expression of Aire, CD80 and Ins1 mRNA in thyms epithelial cells(TEC) of Fatal Thymus Organ culture(FTOC). The trans-location and reduced expression of these mRNAs were detected neither in mouse TEC culture system nor mouse thymus in vivo. These results indicated that translocation of nuclear Aire to cytoplasm inhibit differentiation of TEC, although the phenomenon were specific event in TEC of FTOC. In Sjogren' s syndrome(SS) mouse model, expression of Aire mRNA was totally reduced, however, the expression intensity depends on each lymph node. This result suggested that reduction of AIRE associated with mouse SS developing mechanism.

地塞米松（Dex）诱导FTOC胸腺上皮细胞（TEC）AIRE蛋白由核向胞浆移位，并降低Aire、CD80和Ins1 mRNA的表达。在小鼠TEC培养系统和小鼠胸腺中均未检测到这些mRNA的转位和表达减少。这些结果表明，尽管Aire核转位现象是FTOC TEC的特有现象，但它抑制了TEC的分化。在干燥综合征（SS）小鼠模型中，Aire mRNA的表达完全降低，但表达强度取决于每个淋巴结。提示AIRE降低与小鼠SS发生机制有关。

项目成果

イヌ顎骨モデルにおける光触媒超親水性インプラントの骨形成促進効果

光催化超亲水植入物对狗颌骨模型的骨形成促进作用

• 发表时间: 2009
• 作者: 平川祐子;小野大輔;柴田恭明;池田通;澤瀬隆
• 通讯作者: 澤瀬隆

Pathogenesis of middle ear cholesteatoma : a new model of experinentally induced cholesteetoma in Mongolian gerbils.

中耳胆脂瘤的发病机制：蒙古沙鼠实验诱导胆脂瘤的新模型。

• 发表时间: 2010
• 期刊: Am J Pathol
• 影响因子: 6
• 作者: 坂野美栄;田沼順一;山本(福田)智美
• 通讯作者: 山本(福田)智美

生体材料としてのカスタムアバットメントの清浄化に関する研究

作为生物材料清洁定制基台的研究

• 发表时间: 2011
• 作者: 中島和慶;柴田恭明;尾立哲郎;澤瀬隆
• 通讯作者: 澤瀬隆

Improvement of in situ PCR by optimization of PCR cycle number and proteinase k concentration: localization of x chromosome-linked phosphoglycerate kinase-1 gene in mouse reproductive organs.

• DOI: 10.1267/ahc.09011
• 发表时间: 2009-04-28
• 期刊: Acta histochemica et cytochemica
• 影响因子: 2.4
• 作者: Hishikawa Y;An S;Yamamoto-Fukuda T;Shibata Y;Koji T
• 通讯作者: Koji T

Pathogenesis of middle ear cholesteatoma ; a new model of experimentally induced cholesteatoma in Mongolian gerbils.

中耳胆脂瘤的发病机制；

• 发表时间: 2010
• 期刊: Am.J.Pathol. (in press)
• 作者: Yamamoto-Fukuda;T.
• 通讯作者: T.