A study on the mechanisms of tissue repair and regeneration of dentin-pulp complex

本研究的目的是阐明牙齿损伤后牙髓组织修复和修复性牙本质形成过程中的细胞事件。在大鼠磨牙器官培养系统的成纤维细胞中，观察到α-平滑肌肌动蛋白(SMA)表达上调。THY-1阳性的牙髓细胞定位于亚母细胞层，具有向硬组织形成细胞分化的能力。α-SMA阳性和/或Thy-1阳性细胞可能在牙髓的组织修复和再生中发挥作用。

The aim of this study was to elucidate cellular events during pulp tissue repair and reparative dentin formation after tooth injury. The up-regulation ofα-smooth muscle actin(SMA) was characteristically observed in fibroblastic cells in an organ culture system of rat molar. Thy-1-positive dental pulp cells localized in the subodontoblastic layer had the ability to differentiate into hard tissue-forming cells. Theα-SMA-positive and/or Thy-1-positive cells may play a role in tissue repair and regeneration of dental pulp.