Regenerative medicine for diabetic polyneuropathy using dental pulp stem cells

利用牙髓干细胞治疗糖尿病多发性神经病的再生医学

• 批准号: 21592506
• 负责人: NARUSE Keiko
• 金额: $ 2.83万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592506/
• 关键词: 歯髄幹細胞; 糖尿病性神経障害; 細胞治療; 再生; 細胞移植

In this study, we examined whether transplantation of rat or human DPSCs improve diabetic polyneuropathy. DPSCs were injected into unilateral hindlimb skeletal muscles of streprozotocin-induced diabetic animals. Transplantation of DPSCs ameliorated the decrease of sensation, sciatic nerve conduction velocity and sciatic nerve blood flow under the diabetic condition. Immunohistological study revealed that transplanted DPSCs existed in perimuscle bundle area without differentiation into osteoblasts or adipocytes. These results indicate that DPSCs are promising cell source for regenerative medicine and the transplantation of DPSCs may be a new therapy for diabetic polyneuropathy.

在这项研究中，我们研究了大鼠或人DPSC移植是否改善糖尿病多发性神经病。将DPSC注射到链脲佐菌素诱导的糖尿病动物的单侧后肢骨骼肌中。DPSCs移植可改善糖尿病大鼠感觉功能、坐骨神经传导速度和坐骨神经血流量的下降。免疫组化结果显示，移植的DPSCs主要分布于肌束周围，未分化为成骨细胞和脂肪细胞。这些结果表明，DPSCs是再生医学的一种有希望的细胞来源，DPSCs移植可能成为糖尿病多发性神经病的一种新的治疗方法。

项目成果

Association of resistin polymorphism, its serum levels and prevalence of stroke in Japanese type 2 diabetic patients.

• DOI: 10.1111/j.2040-1124.2010.00040.x
• 发表时间: 2010-08-02
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Nakashima E;Watarai A;Tsukahara T;Hamada Y;Naruse K;Kamiya H;Kato J;Kato N;Tomita M;Oiso Y;Nakamura J
• 通讯作者: Nakamura J

The functions of bone marrow-derived mononuclear cells and their therapeutic efficacy on diabetic polyneuropathy are affected by their age

骨髓源性单核细胞的功能及其对糖尿病多发性神经病的治疗效果受年龄影响

• 发表时间: 2009
• 作者: M Iwai;M Jo;M Ishii;T Mori;Y Harada;近藤正樹
• 通讯作者: 近藤正樹

Impact of long-term statin treatment on coronary plaque composition at angiograp hically severe lesions : a nonrandomized study of the history of long-term statin treatment before coronary angioplasty

长期他汀类药物治疗对血管造影严重病变处冠状动脉斑块成分的影响：冠状动脉血管成形术前长期他汀类药物治疗史的非随机研究

• 发表时间: 2009
• 期刊: Clinical Therapeutics 31
• 作者: Tomoyuki Yasukawa;et al;Motohiro Miyagi
• 通讯作者: Motohiro Miyagi

Fabrication of an Orbital Prosthesis Using a Noncontact Three-Dimensional Digitizer and Rapid-Prototyping System

• DOI: 10.1111/j.1532-849x.2010.00655.x
• 发表时间: 2010-12-01
• 期刊: JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
• 影响因子: 4
• 作者: Yoshioka, Fumi;Ozawa, Shogo;Tanaka, Yoshinobu
• 通讯作者: Tanaka, Yoshinobu

糖尿病合併症、今日の治療指針

糖尿病并发症，当今的治疗指南

• 发表时间: 2011
• 作者: 舘原誠晃;宮本洋二;永井宏和;藤澤健司;桃田幸弘;湯浅哲也;高野栄之;福田雅幸;植野高章;近藤正樹;永井宏和;成瀬桂子
• 通讯作者: 成瀬桂子