Regenerative medicine for diabetic polyneuropathy using dental pulp stem cells

在这项研究中，我们研究了大鼠或人DPSC移植是否改善糖尿病多发性神经病。将DPSC注射到链脲佐菌素诱导的糖尿病动物的单侧后肢骨骼肌中。DPSCs移植可改善糖尿病大鼠感觉功能、坐骨神经传导速度和坐骨神经血流量的下降。免疫组化结果显示，移植的DPSCs主要分布于肌束周围，未分化为成骨细胞和脂肪细胞。这些结果表明，DPSCs是再生医学的一种有希望的细胞来源，DPSCs移植可能成为糖尿病多发性神经病的一种新的治疗方法。

In this study, we examined whether transplantation of rat or human DPSCs improve diabetic polyneuropathy. DPSCs were injected into unilateral hindlimb skeletal muscles of streprozotocin-induced diabetic animals. Transplantation of DPSCs ameliorated the decrease of sensation, sciatic nerve conduction velocity and sciatic nerve blood flow under the diabetic condition. Immunohistological study revealed that transplanted DPSCs existed in perimuscle bundle area without differentiation into osteoblasts or adipocytes. These results indicate that DPSCs are promising cell source for regenerative medicine and the transplantation of DPSCs may be a new therapy for diabetic polyneuropathy.