The elucidation of molecule morbidity of Aurora kinase in oral squamous cell carcinoma, and the application to the medical treatment strategy

在考虑以Aurora为靶点的药物治疗策略的情况下，旨在阐明其分子背景（表达模式、激活机制）及其病理意义。尝试在鳞状细胞癌细胞中稳定表达融合GFP的每一种Aurora蛋白，并利用激光共聚焦扫描显微镜实时观察每一种Aurora蛋白的胞内动态。有可能极光是一个有效的分子靶标。

It aimed at the elucidation of a molecule background(an expression pattern, an activation mechanism) and pathological significance under considering the medical treatment strategy which made Aurora the target. Establishment of stable expression of each Aurora protein that fused GFP in squamous cell carcinoma cell line was tried, and it succeeded in visualizing the intracellular dynamic state of each Aurora in real time by using of a confocal laser scanning microscope. A possibility that Aurora was an effective molecule target was shown.