The elucidation of molecule morbidity of Aurora kinase in oral squamous cell carcinoma, and the application to the medical treatment strategy

口腔鳞状细胞癌中极光激酶分子发病机制的阐明及其在医疗策略中的应用

• 批准号: 21592552
• 负责人: KONDO Seiji
• 金额: $ 2.91万
• 依托单位: Showa University (2010-2011)Shimane University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592552/
• 关键词: 分裂期キナーゼ; Aurora

It aimed at the elucidation of a molecule background(an expression pattern, an activation mechanism) and pathological significance under considering the medical treatment strategy which made Aurora the target. Establishment of stable expression of each Aurora protein that fused GFP in squamous cell carcinoma cell line was tried, and it succeeded in visualizing the intracellular dynamic state of each Aurora in real time by using of a confocal laser scanning microscope. A possibility that Aurora was an effective molecule target was shown.

在考虑以Aurora为靶点的药物治疗策略的情况下，旨在阐明其分子背景（表达模式、激活机制）及其病理意义。尝试在鳞状细胞癌细胞中稳定表达融合GFP的每一种Aurora蛋白，并利用激光共聚焦扫描显微镜实时观察每一种Aurora蛋白的胞内动态。有可能极光是一个有效的分子靶标。

项目成果

Regulation of chondrocytic phenotype by micro RNA 18a : involvement of Ccn2/Ctgf as a major terget gene

微小RNA 18a对软骨细胞表型的调节：Ccn2/Ctgf作为主要目标基因的参与

• 发表时间: 2009
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: T. Ohgawara;S. Kubota;H. Kawaki;S. Kondo;T. Eguchi;N Kurio;E. Aoyama;A. Sasaki;M. Takigawa
• 通讯作者: M. Takigawa

A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA Journal of Cellular Biochemistry

增强鸡 ccn1 mRNA 核糖体募集的编码 RNA 片段 细胞生物化学杂志

• 发表时间: 2010
• 作者: Y. Mukudai;S. Kubota;T. Eguchi;K. Sumiyoshi;D. Janune;S. Kondo;S. Shintani;M. Takigawa
• 通讯作者: M. Takigawa

Glyceraldehyde-3-phosphate dehydrogenaseはCCN 2 mRNA結合蛋白である

3-磷酸​​甘油醛脱氢酶是一种 CCN 2 mRNA 结合蛋白

• 发表时间: 2011
• 作者: 近藤誠二;ら
• 通讯作者: ら

Role of the low-density lipoproprotein receptor-related protein-1 in regulation of chondrocyte differentiation

低密度脂蛋白受体相关蛋白1在软骨细胞分化调节中的作用

• 发表时间: 2010
• 期刊: Journal of Cellular Physiology
• 影响因子: 5.6
• 作者: K. Kawata;S. Kubota;T. Eguchi;N. H. Moritani;T. Shimo;S. Kondo;T. Nishida;S. Minagi;M. Takigawa
• 通讯作者: M. Takigawa

天然生薬エキスによる口腔癌治療創薬への挑戦

使用天然草药提取物治疗口腔癌的药物发现挑战

• 发表时间: 2010
• 作者: 近藤誠二;et al.
• 通讯作者: et al.