Role on novel protein in alveolar bone remodeling mechanism of tooth movement

在这项研究中，我们研究了PRIP-2的基因结构，它表现出普遍的表达。我们发现了PRIP-2基因的几个转录起始位点。为了研究PRIP-2基因在牙齿移动过程中的作用，本研究采用Real-time PCR技术，对正畸力作用下牙齿移动小鼠的牙槽骨改建进行了研究。PRIP-1、PRIP-2及GABAA受体各亚基在牙移动小鼠脑组织中的表达水平与对照组相比均无显著性差异。

In this study, we investigated the gene structure of PRIP-2, which exhibited an ubiquitous expression. We found several transcriptional start sites of PRIP-2 gene. This result indicates that PRIP-2 gene produces some transcripts.To examine the role of PRIP molecule on the alveolar bone remodeling mechanism of tooth movement, we carried out Real-time PCR using tooth movement mice by orthodontic force. There was no significantly difference of the expression level of PRIP-1, PRIP-2 and each subunit of GABAA receptor in brain, between the tooth movement mice and the control.