Role on novel protein in alveolar bone remodeling mechanism of tooth movement

在这项研究中，我们研究了普遍表达的PRIP-2的基因结构。我们发现了几个rip -2基因的转录起始位点。这一结果表明，rip -2基因产生了一些转录本。为了研究PRIP分子在牙齿运动的牙槽骨重塑机制中的作用，我们利用正畸力对牙齿运动小鼠进行了Real-time PCR。动牙小鼠与对照组脑内GABAA受体各亚基及PRIP-1、PRIP-2的表达量差异无统计学意义。

In this study, we investigated the gene structure of PRIP-2, which exhibited an ubiquitous expression. We found several transcriptional start sites of PRIP-2 gene. This result indicates that PRIP-2 gene produces some transcripts.To examine the role of PRIP molecule on the alveolar bone remodeling mechanism of tooth movement, we carried out Real-time PCR using tooth movement mice by orthodontic force. There was no significantly difference of the expression level of PRIP-1, PRIP-2 and each subunit of GABAA receptor in brain, between the tooth movement mice and the control.