Role on novel protein in alveolar bone remodeling mechanism of tooth movement

新型蛋白质在牙齿移动牙槽骨重塑机制中的作用

• 批准号: 21792083
• 负责人: MURAKAMI Ayako
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792083/
• 关键词: PRIP; 転写; スプライシング; 歯牙移動; 骨リモデリング; 遺伝子発現調節; 抑制性情報伝逹; メカニカルストレス

In this study, we investigated the gene structure of PRIP-2, which exhibited an ubiquitous expression. We found several transcriptional start sites of PRIP-2 gene. This result indicates that PRIP-2 gene produces some transcripts.To examine the role of PRIP molecule on the alveolar bone remodeling mechanism of tooth movement, we carried out Real-time PCR using tooth movement mice by orthodontic force. There was no significantly difference of the expression level of PRIP-1, PRIP-2 and each subunit of GABAA receptor in brain, between the tooth movement mice and the control.

在这项研究中，我们研究了PRIP-2的基因结构，它表现出普遍的表达。我们发现了PRIP-2基因的几个转录起始位点。为了研究PRIP-2基因在牙齿移动过程中的作用，本研究采用Real-time PCR技术，对正畸力作用下牙齿移动小鼠的牙槽骨改建进行了研究。PRIP-1、PRIP-2及GABAA受体各亚基在牙移动小鼠脑组织中的表达水平与对照组相比均无显著性差异。

项目成果

Studies on characterization of the gene structure and transcriptional regulation of a novel inositol 1,4,5-trisphosphate binding protein, possibly involved in bone metabolism

可能参与骨代谢的新型肌醇1,4,5-三磷酸结合蛋白的基因结构和转录调控特征研究

• 发表时间: 2010
• 作者: Ayako Murakami;Miho Matsuda;Koushirou Tsutsumi;Masato Hirata;Ichiro Takahashi
• 通讯作者: Ichiro Takahashi

Studies on characterization of the gene structure and transcriptional reglatipn of a novel insitol 1,4,5-trisphosphate binding protein, possibly involved in bone metabolism

可能参与骨代谢的新型肌醇1,4,5-三磷酸结合蛋白的基因结构和转录调控的表征研究

• 发表时间: 2009
• 作者: 中尾紀子;渡邊悦子;松永淳子;白石孝信;渡邊郁哉;吉田教明;Ayako Murakami
• 通讯作者: Ayako Murakami