Roles of a novel protein in alveolar bone remodeling process

在这项研究中，我们调查了PRIP在正畸牙齿移动过程中牙槽骨改建的可能参与。在PRIP-KO小鼠中，与WT小鼠相比，牙齿移动似乎减少。组织学分析显示，成骨细胞在牙槽骨张力侧和破骨细胞在压力侧的分布不同。与WT小鼠相比，KO小鼠中分化的破骨细胞群体减少。这些结果表明PRIP参与了机械性牙齿移动过程中骨重建的调节

In this study, we investigated the possible involvement of PRIP in alveolar bone remodeling during orthodontic tooth movement. In PRIP-KO mice, tooth movement appeared to be reduced compare to the WT mice. Histological analysis showed the difference in distributions of osteoblasts on the tension side and osteoclasts on the pressure side of alveolar bones, respectively. Population of differentiated osteoclasts was decreased in KO mice compared with WT mice. These results indicate that PRIP is implicated in the regulation of bone remodeling during mechanical tooth movement