Mechanisms of T cell function disorder in periodontal diseases by butyrate and gingival fibroblast

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This study focused on the effect of gingival fibroblasts (GF) on impairment of immune responses in periodontal tissues caused by butyrate secreted from periodontopathic bacteria. It was suggested that GF which was prepared from periodontal diseases patients and sensitive to butyrate-dependent cell death failed to inhibit the butyrate-dependent cell death of T cells. On the contrary, butyrate-resistant healthy GF suppressed the cell death of T cells. Moreover, butyrate modified cytokine production from helper T cell subsets independently of GF. These results may imply additional mechanisms by which periodontopathic bacteria and butyrate impair the immune responses in periodontal tissues.