Development of DNA-Chip-Based Electronic Devices for Nanobio Sensing Applications

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DNA-based molecular device that is capable of responding to biological molecular recognition events was tackled for futuristic nano-, bio-device developments based on in-situ electoconductive modification of DNA self-assembly. Some direct or indirect assistance necessary to the goal were successfully developed; novel psoralen compounds that enable versatile functionalization of DNA duplexes by covalent conjugation, single-molecule assay for various DNA affinity reactions including single-nucleotide polymorphism using atomic force microscope, new types of bottom-up, supramolecular DNA nanomaterials based on dendrimer formation of three-way junction DNA, and etc. We are committed to taking on the challenges by installing the DNA dendrimer materials into interdigitated array electrode to provide state-of-the-art, molecularly responsive devices adaptable to various bioanalytical purposes.