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Establishment of a new paradigm in the phosphoinositide research

Establishment of a new paradigm in the phosphoinositide research
建立磷酸肌醇研究新范式
批准号:
21200075
负责人:
SASAKI Junko
金额:
$18.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
There are two isozymes (L-PIPase and P-PIPase) which dephosphorylate PI(3,4)P2. However the functions of L-PIPase and P-PIPase are unclear. In this study we showed that L-PIPase suppresses neuronal cell death after brain ischemia while P-PIPase contributes to malignant progression. We also found that each enzyme has different activities against several PI(3,4)P2 species. It is suggested that the different functions between L-PIPase and P-PIPase might be caused by the substrate specificity.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [D. Tokuhara, B. Gonzalez, M. Mejima, Y. Takahashi, S. Kurokawa, T. Hiroiwa, M. Kuroda, M. Oyama, H. Kozuka-Hata, T. Nochi, F. Aladin, H. Marcotte, L. Frenken, M. Iturriza, H. Kiyono, L. Hammarstrom, & Y. Yuki, 井上貴雄]
通讯作者: 井上貴雄
DOI: 10.1111/j.1440-1746.2010.06327.x
发表时间: 2011-01-01
期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
影响因子: 4.1
作者: [Kinoshita, Nobukatsu, Horie, Yasuo, Ohnishi, Hirohide]
通讯作者: Ohnishi, Hirohide
The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death
脂质磷酸酶 INPP4A 可防止纹状体神经元兴奋性毒性死亡
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ogino, Hajime, 佐々木純子]
通讯作者: 佐々木純子
DOI: 10.1073/pnas.1016430108
发表时间: 2011-04-05
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Kobayashi, Naoki, Ueki, Kohjiro, Kadowaki, Takashi]
通讯作者: Kadowaki, Takashi
9
    Molecular Species of phosphoinositides and their functions
    • 批准号:
      24390067
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2012
    • 负责人:
      SASAKI Junko
    • 依托单位:
    Regulation of inflammatory cytokine processing by a phospholipid-metabolizing enzyme.
    • 批准号:
      21790262
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2009
    • 负责人:
      SASAKI Junko
    • 依托单位:
    Chinese Chapbooks : A Survey on Printed Books of Quyi Kept in European Libraries
    • 批准号:
      17520097
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.22万
    • 财政年份:
      2005
    • 负责人:
      SASAKI Junko
    • 依托单位:
    海外基金