Establishment of a new paradigm in the phosphoinositide research

建立磷酸肌醇研究新范式

• 批准号: 21200075
• 负责人: SASAKI Junko
• 金额: $ 18.39万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21200075/
• 关键词: 分子病態学; シグナル伝達; 脂質; 細胞・組織

There are two isozymes (L-PIPase and P-PIPase) which dephosphorylate PI(3,4)P2. However the functions of L-PIPase and P-PIPase are unclear. In this study we showed that L-PIPase suppresses neuronal cell death after brain ischemia while P-PIPase contributes to malignant progression. We also found that each enzyme has different activities against several PI(3,4)P2 species. It is suggested that the different functions between L-PIPase and P-PIPase might be caused by the substrate specificity.

有两种使PI（3，4）P2去磷酸化的同工酶（L-PIPase和P-PIPase）。然而，L-PIPase和P-PIPase的功能尚不清楚。在这项研究中，我们发现L-PIPase抑制脑缺血后神经元细胞死亡，而P-PIPase有助于恶性进展。我们还发现每种酶对几种PI（3，4）P2物种具有不同的活性。提示L-PIPase和P-PIPase的不同功能可能是由底物特异性引起的。

项目成果

Identification of enzymes involved in fatty acid remodeling of phosphatidylinositol

参与磷脂酰肌醇脂肪酸重塑的酶的鉴定

• 发表时间: 2010
• 作者: D. Tokuhara;B. Gonzalez;M. Mejima;Y. Takahashi;S. Kurokawa;T. Hiroiwa;M. Kuroda;M. Oyama;H. Kozuka-Hata;T. Nochi;F. Aladin;H. Marcotte;L. Frenken;M. Iturriza;H. Kiyono;L. Hammarstrom;& Y. Yuki;井上貴雄
• 通讯作者: 井上貴雄

Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury

• DOI: 10.1111/j.1440-1746.2010.06327.x
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 4.1
• 作者: Kinoshita, Nobukatsu;Horie, Yasuo;Ohnishi, Hirohide
• 通讯作者: Ohnishi, Hirohide

The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death

脂质磷酸酶 INPP4A 可防止纹状体神经元兴奋性毒性死亡

• 发表时间: 2010
• 作者: Ogino;Hajime;佐々木純子
• 通讯作者: 佐々木純子

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

• DOI: 10.1073/pnas.1016430108
• 发表时间: 2011-04-05
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Kobayashi, Naoki;Ueki, Kohjiro;Kadowaki, Takashi
• 通讯作者: Kadowaki, Takashi

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes

• DOI: 10.1073/pnas.1109101108
• 发表时间: 2011-09-20
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Uchida, Yasunori;Hasegawa, Junya;Arai, Hiroyuki
• 通讯作者: Arai, Hiroyuki