Establishment of a new paradigm in the phosphoinositide research
Establishment of a new paradigm in the phosphoinositide research
批准号:
21200075
负责人:
SASAKI Junko
金额:
$18.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
There are two isozymes (L-PIPase and P-PIPase) which dephosphorylate PI(3,4)P2. However the functions of L-PIPase and P-PIPase are unclear. In this study we showed that L-PIPase suppresses neuronal cell death after brain ischemia while P-PIPase contributes to malignant progression. We also found that each enzyme has different activities against several PI(3,4)P2 species. It is suggested that the different functions between L-PIPase and P-PIPase might be caused by the substrate specificity.
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Identification of enzymes involved in fatty acid remodeling of phosphatidylinositol
参与磷脂酰肌醇脂肪酸重塑的酶的鉴定
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[D. Tokuhara, B. Gonzalez, M. Mejima, Y. Takahashi, S. Kurokawa, T. Hiroiwa, M. Kuroda, M. Oyama, H. Kozuka-Hata, T. Nochi, F. Aladin, H. Marcotte, L. Frenken, M. Iturriza, H. Kiyono, L. Hammarstrom, & Y. Yuki, 井上貴雄]
通讯作者:
井上貴雄
DOI:
10.1111/j.1440-1746.2010.06327.x
发表时间:
2011-01-01
期刊:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
影响因子:
4.1
作者:
[Kinoshita, Nobukatsu, Horie, Yasuo, Ohnishi, Hirohide]
通讯作者:
Ohnishi, Hirohide
The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death
脂质磷酸酶 INPP4A 可防止纹状体神经元兴奋性毒性死亡
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ogino, Hajime, 佐々木純子]
通讯作者:
佐々木純子
DOI:
10.1073/pnas.1016430108
发表时间:
2011-04-05
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Kobayashi, Naoki, Ueki, Kohjiro, Kadowaki, Takashi]
通讯作者:
Kadowaki, Takashi
DOI:
10.1073/pnas.1109101108
发表时间:
2011-09-20
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Uchida, Yasunori, Hasegawa, Junya, Arai, Hiroyuki]
通讯作者:
Arai, Hiroyuki
共 9 条
Molecular Species of phosphoinositides and their functions
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批准号:24390067
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
-
财政年份:2012
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负责人:SASAKI Junko
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依托单位:
Regulation of inflammatory cytokine processing by a phospholipid-metabolizing enzyme.
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批准号:21790262
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:SASAKI Junko
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依托单位:
Chinese Chapbooks : A Survey on Printed Books of Quyi Kept in European Libraries
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批准号:17520097
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.22万
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财政年份:2005
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负责人:SASAKI Junko
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依托单位:
海外基金