Signal transduction networks regulating life span and development

我们发现，由应激响应的MAP激酶JNK和转录因子AP-1组成的信号通路对于秀丽隐杆线虫禁食诱导的寿命延长至关重要。我们还发现，在早期非洲爪蟾胚胎发育过程中，激酶SGK1通过非细胞自主的信号通路促进外胚层细胞的存活。此外，我们发现了在哺乳动物骨骼肌分化过程中调节细胞融合的信号通路。此外，我们确定了骨骼肌和脂肪分化程序之间的拮抗相互作用。

We found that a signaling pathway consisting of the stress-responsive MAP kinase JNK and the transcription factor AP-1 is essential for fasting-induced extension of life span in C. elegans. We also found that the kinase SGK1 promotes ectodermal cell survival during early Xenopus embryonic development through a non-cell-autonomous signaling pathway. Furthermore, we identified a signaling pathway regulating cell fusion during mammalian skeletal muscle differentiation. Also, we identified an antagonistic interaction between skeletal muscle and adipose differentiation programs.