Molecular mechanisms of subcellular synapse organization in cerebellar Purkinje neurons

神经元连接的一个显著特征是它的特异性。沿浦肯野神经元输入谷氨酸能和gaba能的亚细胞组织对小脑的信息加工至关重要。在这项研究中，我们证明了RBP-J促进星状细胞和篮状细胞的神经发生：两组抑制性神经元分别选择性地支配浦肯野神经元的树突和轴突初始段。此外。我发现，在zebrin II免疫反应区（Z+）支配浦肯野神经元近端树突的攀爬纤维（CF_s）比在Z区有更高的释放概率。

A remarkable feature of neuronal wiring is its specificity. The subcellular organization of glutamatergic and GABAergic inputs along Purkinje neurons is essential for information processing in cerebellum. In this study, we demonstrated that RBP-J promotes the neurogenesis of stellate and basket cells : two sets of inhibitory neurons that innervate selectively dendrites and axonal initial segments of Purkinje neurons, respectively. In addition. I found that climbing fibers(CF_s) that innervate proximal dendrites of Purkinje neurons in zebrin II immunoreactive(Z+) zones have a higher release probability than CFs in Z-zones.