New Aspects of Catalytic Trans form ation of Alcohols Using Metal Alkoxides Having Protic Ligands

本课题研究的重点是如何在有机合成中利用新的分子催化剂来控制和改变醇作为亲电性(R^+-^OH)和亲核性(R^+-^OH)的反应性。在本项目中，我们新引入并验证了分子表面这一新概念在这些催化剂中的重要性。总之，我们证明了在近中性pH条件下，由RO(δ-)-M(δ+)-X(δ-)-H(δ+)所代表的由特殊元素和键排列组成的分子表面对于实现其他困难的催化是重要的。

The research project was focused on how we could control and alter the reactivity of alcohols as electrophile(R^+-^OH) nucleophile(R^+-^OH) using new molecular catalyses in organic synthesis. Importance of a new concept“molecular surface"in those catalyses was newly introduced and validated during the project. Overall, we demonstrated that molecular surface consisting of special element and bond alignment as represented by RO(δ-)-M(δ+)-X(δ-)-H(δ+) is important to achieve otherwise difficult catalysis under near neutral pH conditions.