Oligomer forming mechanism of lectin-like oxidized LDL receptor-1(LOX-1), and its functional reconstitution.

凝集素样氧化型低密度脂蛋白受体-1(LOX-1)识别氧化型低密度脂蛋白，启动内皮功能障碍，这被认为是动脉粥样硬化的关键早期步骤。在这里，我们展示了LOX-1是如何形成功能单位的，并成功地重建了LOX-1的结合能力。此外，我们还开发了分子装置来评估氧化应激导致的OxLDL的形成和分子种类。

Lectin-like oxidized LDL receptor-1(LOX-1) recognizes oxidized LDL and initiates endothelial dysfunction, which is believed to be a crucial early step in atherosclerosis. Here we show how LOX-1 forms the functional unit, and succeed to reconstitute the binding ability of LOX-1.Moreover, we develop molecular device to evaluate the OxLDL formation and molecular species, which produced on OxLDL as the results of oxidative stress.