Mechanism of nano-particle translocation at the air-bloodbarrier and its effects on health

将纳米颗粒(C60富勒烯、胶体金)暴露于小鼠呼吸道后，通过光镜、免疫组织化学和电子显微镜观察纳米颗粒的定位和转运途径，以及纳米颗粒对组织的影响。纳米颗粒在呼吸系统中没有显示出组织损伤的迹象。结合扩散和小凹介导的内吞作用被认为是暴露的纳米颗粒的移位途径。

After exposure of nano-particles(C60 Fullerene, colloidal gold) into the respiratory tract of mice, localization and translocation pathway of the particles, effects of the particles on the tissues were examined with the use of light microscopy, immunohistochemistry and electron microscopy. Nano-particles showed no signs of tissue damage in the respiratory system. Association of diffusion and caveolae mediated endocytosis were indicated as the translocation pathway of the exposed nano-particles.