Mechanism of nano-particle translocation at the air-bloodbarrier and its effects on health

纳米颗粒气血屏障易位机制及其对健康的影响

• 批准号: 21380181
• 负责人: SHIMADA Akinori
• 金额: $ 4.91万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380181/
• 关键词: ナノ粒子; 空気血液関門; 突破機序; エンドサイトーシス; カベオラ; 免疫組織化学; 免疫電顕; 浮遊粒子状物質; フラーレン

After exposure of nano-particles(C60 Fullerene, colloidal gold) into the respiratory tract of mice, localization and translocation pathway of the particles, effects of the particles on the tissues were examined with the use of light microscopy, immunohistochemistry and electron microscopy. Nano-particles showed no signs of tissue damage in the respiratory system. Association of diffusion and caveolae mediated endocytosis were indicated as the translocation pathway of the exposed nano-particles.

将纳米颗粒（C60富勒烯、胶体金）暴露于小鼠呼吸道后，利用光镜、免疫组织化学和电镜观察其定位和易位途径以及对组织的影响。纳米颗粒在呼吸系统中没有显示出组织损伤的迹象。扩散和小泡介导的内吞作用是暴露的纳米颗粒的易位途径。

项目成果

Translocation pathway of the intratracheally instilled C60 Fullerene from the lung into the blood circulation in mouse : possible association of diffusion and caveolae mediated pinocytosis

气管内滴注C60富勒烯从肺部进入小鼠血液循环的易位途径：扩散和小窝介导的胞饮作用的可能关联

• 发表时间: 2009
• 期刊: Toxicologic Pathology
• 影响因子: 1.5
• 作者: Naota M;Shimada A;Morita T;Inoue K;Takano H.
• 通讯作者: Takano H.

Pathological study on the pulmonary toxicity induced by the intratracheally instilled Asian sand dust in mice

气管内滴注亚洲沙尘致小鼠肺毒性的病理学研究

• 发表时间: 2009
• 作者: El-Habashi N;El-Nahass E;Fukushi H;Nayel M;Hibi D;Sakai H;Yanai T;Naota M.
• 通讯作者: Naota M.

気管内投与黄砂粒子の急性肺毒性についての病理学的研究

黄沙颗粒气管给药急性肺毒性的病理学研究

• 发表时间: 2009
• 作者: Yamanaka;K.;Saito;Y.;Yamamori;T.;Urano;Y.;Noguchi;N.;直田みさき
• 通讯作者: 直田みさき

Caveolae-mediated Endocytosis of Intratracheally Instilled Gold Colloid Nanoparticles at the Air-Blood Barrier in Mice

• DOI: 10.1177/0192623312457271
• 发表时间: 2013-04-01
• 期刊: TOXICOLOGIC PATHOLOGY
• 影响因子: 1.5
• 作者: Naota, Misaki;Shimada, Akinori;Takano, Hirohisa
• 通讯作者: Takano, Hirohisa