Molecular identification and physiological role of brain-type prostaglandin transporter
Molecular identification and physiological role of brain-type prostaglandin transporter
批准号:
21390042
负责人:
HOSOYA Ken-ichi
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Our in vivo and in vitro studies revealed that PGD_2 and PGE_2, which are major prostaglandins in the brain, were eliminated from rat cerebroventricle across the blood-cerebrospinal fluid barrier(BCSFB). To examine the involvement of brain-type prostaglandin transporter(PGT-Br) in this elimination process, PGT-Br-expressing Xenopus Laevis oocytes were established. The PGD_2 uptake activity into PGT-Br-expressing oocytes was high, but not significantly altered, compared with water-injected oocytes
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Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders.
血脑屏障和血红脊髓液屏障的鸟可以化合物的转运特性:与神经疾病有关。
DOI:
10.1186/2045-8118-8-13
发表时间:
2011-02-28
期刊:
Fluids and barriers of the CNS
影响因子:
7.3
作者:
[Tachikawa M, Hosoya K]
通讯作者:
Hosoya K
脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析
前列腺素E合酶在大脑中的表达和前列腺素E_2从心室的输出转运分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[小関剛, 辻和宏, 赤沼伸乙, 立川正憲, 細谷健一]
通讯作者:
細谷健一
Organic anion transporter3を介したprostaglandin E_2輸送機能解析
有机阴离子转运蛋白3对前列腺素E_2转运功能的分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[樋口貴則, 赤沼伸乙, 立川正憲, 細谷健一]
通讯作者:
細谷健一
Organic anion transporter 3を介したprostaglandin E2輸送機能解析
有机阴离子转运蛋白 3 前列腺素 E2 转运功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[樋口貴則, 他]
通讯作者:
他
MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE2排出の阻害
施用MRP4功能抑制药物抑制PGE2通过血脑屏障从小鼠大脑流出
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[赤沼伸乙, 伊藤慎悟, 立川正憲, 大槻純男, 細谷健一, 寺崎哲也]
通讯作者:
寺崎哲也
共 20 条
Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.
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批准号:16K15157
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2016
-
负责人:HOSOYA Ken-ichi
-
依托单位:
Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases
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批准号:24659072
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2012
-
负责人:HOSOYA Ken-ichi
-
依托单位:
Antioxidants transport via GLUT1 at the blood-retinal barrier
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批准号:15390046
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
-
财政年份:2003
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负责人:HOSOYA Ken-ichi
-
依托单位:
Development of inner blood-retinal barrier cell lines from transgehic rats harboring temperature-sensitive SV40 large T-antigen gene
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批准号:12557226
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.19万
-
财政年份:2000
-
负责人:HOSOYA Ken-ichi
-
依托单位:
Molecular analysis of cell growth regulating factor in retinal, capillary endothelial cells
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批准号:12672206
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
-
财政年份:2000
-
负责人:HOSOYA Ken-ichi
-
依托单位:
海外基金