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Molecular identification and physiological role of brain-type prostaglandin transporter

Molecular identification and physiological role of brain-type prostaglandin transporter
脑型前列腺素转运蛋白的分子鉴定及其生理作用
批准号:
21390042
负责人:
HOSOYA Ken-ichi
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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英文摘要
Our in vivo and in vitro studies revealed that PGD_2 and PGE_2, which are major prostaglandins in the brain, were eliminated from rat cerebroventricle across the blood-cerebrospinal fluid barrier(BCSFB). To examine the involvement of brain-type prostaglandin transporter(PGT-Br) in this elimination process, PGT-Br-expressing Xenopus Laevis oocytes were established. The PGD_2 uptake activity into PGT-Br-expressing oocytes was high, but not significantly altered, compared with water-injected oocytes
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Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders.
血脑屏障和血红脊髓液屏障的鸟可以化合物的转运特性:与神经疾病有关。
DOI: 10.1186/2045-8118-8-13
发表时间: 2011-02-28
期刊: Fluids and barriers of the CNS
影响因子: 7.3
作者: [Tachikawa M, Hosoya K]
通讯作者: Hosoya K
脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析
前列腺素E合酶在大脑中的表达和前列腺素E_2从心室的输出转运分析
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小関剛, 辻和宏, 赤沼伸乙, 立川正憲, 細谷健一]
通讯作者: 細谷健一
Organic anion transporter3を介したprostaglandin E_2輸送機能解析
有机阴离子转运蛋白3对前列腺素E_2转运功能的分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [樋口貴則, 赤沼伸乙, 立川正憲, 細谷健一]
通讯作者: 細谷健一
Organic anion transporter 3を介したprostaglandin E2輸送機能解析
有机阴离子转运蛋白 3 前列腺素 E2 转运功能分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [樋口貴則, 他]
通讯作者:
20
    Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.
    • 批准号:
      16K15157
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2016
    • 负责人:
      HOSOYA Ken-ichi
    • 依托单位:
    Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases
    • 批准号:
      24659072
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      HOSOYA Ken-ichi
    • 依托单位:
    Antioxidants transport via GLUT1 at the blood-retinal barrier
    Development of inner blood-retinal barrier cell lines from transgehic rats harboring temperature-sensitive SV40 large T-antigen gene
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