Regulation of aquaporin-4 by formation of protein complex and orthogonal array

点击翻译按钮获取中文摘要

To investigate physiological roles of square array formation of aquaporin-4 (AQP4) in vivo, we established two kinds of AQP4 knockout mice: M1 isoform-specific KO, which is expected to possess much larger arrays than wild type, and null mice. As a result of comprehensive phenotype analysis, we found that appropriate size of the square arrays is essential for the retinal response to light stimulation. In addition, we demonstrated that AQP4 plays an important role for immunological function in the central nervous system by making stub-wounded model using AQP4-null mice. Both types of knockout mice have been deposited at RIKEN BRC so as to be used freely by other researchers.