Molecular Mechanisms to Regulate The Metabolism of Water and Electrolytes

为了阐明肾单位远端小管和集合管水和电解质重吸收的分子调控机制，我们证明了钙调神经磷酸酶参与了血管紧张素II依赖性醛固酮分泌的信号通路。此外，我们发现，缺乏mascurin基因的原因耗尽的抗利尿激素（加压素）。最后，当给予硫酸化糖脂缺陷小鼠高盐浓度的水时，尿量和水摄入量增加。然而，水通道蛋白和Na^+，K^+-ATP酶的表达水平和膜定位没有恶化。

Aiming at elucidation of molecular regulatory mechanisms underlying the reabsorption of water and electrolytes on the distal tubules and collecting ducts of the nephron, we demonstrated calcineurin is involved in the signaling pathway dictating the angiotensin II-dependent aldosteron secretion. Further, we found that deficiency of the mascurin gene causes depletion of the antidiuretic hormone(vasopressin). Finally, amounts of urine and water intake were increased when a high salt concentration of water was given to the sulfated glycolipid-deficient mice. However expression levels and membrane localizations of aquaporin and Na^+, K^+-ATPase were not deteriorated.