Funtion and differentiation of a specialized subset of intestinal epithelial M cells
Funtion and differentiation of a specialized subset of intestinal epithelial M cells
批准号:
21390155
负责人:
OHNO Hiroshi
金额:
$11.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Taking advantage of the fact that exogenously administered RANKL induces ectopic M-cell differentiation in murine small intestinal epithelium, we established an evaluation system for M-cell differentiation. By using the system, we have identified the transcription factor Spi-B to be specifically expressed in M cells and essential for their differentiation. Spi-B KO mice, lacking M cells, failed to evoke normal immune responses toward orally infected Salmonella Typhimurium, indicating that antigen uptake by M cells is critical for efficient intestinal immune responses.
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Identification of RNA aptamers targeting mouse GP2 proteins by SELEX
SELEX 鉴定靶向小鼠 GP2 蛋白的 RNA 适体
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Hanazato, M., Nakato, G., Nishikawa, F., Hase, K. Nishikawa, S., Ohno, H.]
通讯作者:
H.
M-Secによる細胞間ナノチューブ形成促進の分子機構
M-Sec促进细胞间纳米管形成的分子机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[長谷耕二, 高津宏之, 木村俊介, 大野博司]
通讯作者:
大野博司
NALTにおけるM細胞を介した粘膜免疫応答
NALT 中 M 细胞介导的粘膜免疫反应
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[伊達康博、海老澤昌史、福田真嗣、尾畑祐樹、高橋大輔、嶋秀明、花里美紗穂、中藤学、常田聡、Williams, I. R.、長谷耕二、大野博司]
通讯作者:
I. R.、長谷耕二、大野博司
DOI:
10.1093/intimm/dxq478
发表时间:
2011-04-01
期刊:
INTERNATIONAL IMMUNOLOGY
影响因子:
4.4
作者:
[Ebisawa, Masashi, Hase, Koji, Ohno, Hiroshi]
通讯作者:
Ohno, Hiroshi
Spatial and temporal specific expression patterns of RANK and RANKL in developing peripheral lymphoid organs
RANK和RANKL在发育中的外周淋巴器官中的时空特异性表达模式
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A. Okamoto, Y, Kasama Y., Sugiyama. M.]
通讯作者:
Sugiyama. M.
共 34 条
Elucidation of the molecular basis of neurogenesis by regulation of fatty acid composition
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批准号:20K19669
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项目类别:Grant-in-Aid for Early-Career Scientists
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资助金额:$2.66万
-
财政年份:2020
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负责人:OHNO Hiroshi
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依托单位:
Comprehensive understanding of a unique intestinal epithelial M cells specialized for luminal particulate antigen uptake
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批准号:24249029
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.79万
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财政年份:2012
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负责人:OHNO Hiroshi
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依托单位:
Analysis of cell-type specific adaptor protein (AP) complexes in cells and organisms
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批准号:15370042
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2003
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负责人:OHNO Hiroshi
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依托单位:
Mechanisms for regulation of intracellular protein sorting mediated by the adaptor protein (AP) complex family
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批准号:12480178
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2000
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负责人:OHNO Hiroshi
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依托单位:
Mechanism of regulation of selective intracellular protein sorting by the family of Adaptor (-like) protein complexes
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批准号:10480155
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.26万
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财政年份:1998
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负责人:OHNO Hiroshi
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依托单位:
海外基金