Roles of basophils in the inductions of Th2 cells and allergy

在各种条件下，嗜碱性细胞表达主要组织相容性复合体II类、CD80、CD86并产生白细胞介素4（IL-4）。嗜碱性粒细胞，当与IL-3和抗原或抗原孵育。IgE复合物，内化，加工和呈递抗原作为肽- mhc II类复合物并产生IL-4。将卵清蛋白（OVA）脉冲的嗜碱性粒细胞静脉注入幼稚小鼠，可优先诱导幼稚OVA特异性CD4^+T细胞发育为T_H2细胞。这种免疫小鼠，当iv给药OVA时，迅速产生OVA特异性的IgG1和IgE。最后，只有在内源性嗜碱性粒细胞存在的情况下，静脉注射IgE复合物才能快速诱导T_H2细胞，这表明嗜碱性粒细胞是有效的抗原呈递细胞，通过捕获IgE复合物优先增强T_H2-IgE反应。

Basophils express major histocompatibility complex class II, CD80, CD86 and produce interleukin 4(IL-4) under various conditions. Basophils, when incubated with IL-3 and antigen or antigen. IgE complexes, internalized, processed and presented antigen as peptide-MHC class II complexes and produced IL-4.Intravenous administration of ovalbumin(OVA)-pulsed basophils into naive mice preferentially induced the development of naive OVA-specific CD4^+T cells into T_H2 cells. Such immunized mice, when challenged by iv administration of OVA, promptly produced OVA-specific IgG1 and IgE. Finally, iv administration of IgE complexes rapidly induced T_H2 cells only in the presence of endogenous basophils, suggesting that basophils are potent antigen-presenting cells that preferentially augment T_H2-IgE responses by capturing IgE complex.