Analysis of the pathogenesis of allergic rhinitis originated by epithelial cells

过敏性鼻炎经常发展，即使在人没有过敏性体质在花粉季节，以及人与过敏性体质。分为两种类型，分别命名为“特应性过敏性鼻炎”和“突发性过敏性鼻炎”。本研究通过建立上述两种豚草花粉特异性变应性鼻炎小鼠模型，并对其发病机制进行分析。结果表明，鼻粘膜上皮细胞来源的花粉粒IL-33和FcεR1阳性细胞（肥大细胞和嗜碱性粒细胞）在花粉特异性变应性鼻炎的发病机制中起重要作用。

Allergic rhinitis often develop even in people without atopic disposition during pollen season as well as people with a predisposition to atopy. Divided into two types, it was named "atopic allergic rhinitis" and "sudden-onset allergic rhinitis", respectively. In this study, we established above two types of mouse model of ragweed pollen-specific allergic rhinitis, and analyzed the mechanism of its onset. As a result, we revealed that both pollen grains-deriven IL-33 from nasal mucosa epithelial cells and the FcεR1 positive cells(mast cells and basophils) play an important role in the pathogenesis of pollen-specific allergic rhinitis.