Association of regulatory T cells to etiology of children with aplastic anemia

调节性 T 细胞与再生障碍性贫血儿童病因学的关联

• 批准号: 21390309
• 负责人: KOJIMA Seiji
• 金额: $ 8.82万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390309/
• 关键词: Aplastic anemia; regulatory T cell; antithymocyte globulin; 再生不良性貧血; 制御性T細胞; 抗ヒト胸腺グロブリン; IL-10

We investigated the number of Tregs in children with alpastic anemia before and after IST or SCT. Fifty children with severe and very severe AA were enrolled in this study from 2007 to 2010. Surface CD4, CD25 and intracellular FOXP3 expression were examined in peripheral blood mononuclear cells by 3-color flow cytometry. The number of CD4+ CD25+ FOXP3+ Tregs is significantly decreased in patients at diagnosis as compared with normal control. The number of Tregs were significantly increased either after IST or after SCT.

我们调查了患有高山贫血的儿童在IST或SCT前后的TcR数量。2007年至2010年，50名重度和极重度AA儿童入组本研究。采用三色流式细胞术检测外周血单个核细胞表面CD4、CD25和细胞内FOXP3的表达。CD4+ CD25+ FOXP3+ T细胞亚群在确诊时较正常人明显减少。IST后和SCT后TcP均明显增加。

项目成果

Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis.

• DOI: 10.1016/j.bbmt.2009.08.012
• 发表时间: 2009-12
• 期刊: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
• 作者: H. Yagasaki;S. Kojima;H. Yabe;Koji Kato;H. Kigasawa;H. Sakamaki;M. Tsuchida;S. Kato;Takakaza Kawase;H. Muramatsu;Y. Morishima;Y. Kodera

Pediatric AplasticAnemia-Immunosupressive Therapy

小儿再生障碍性贫血-免疫抑制治疗

• 发表时间: 2011
• 作者: Takahashi S;Futatsugi-Yumikura S;Yoshimoto T;Yonehara S;Nakanishi K.;Takahashi Y.
• 通讯作者: Takahashi Y.

Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan

日本小儿白血病、骨髓衰竭和造血干细胞移植的进展

• 发表时间: 2010
• 作者: Mizukami;H.;Chaimongkol N;Kojima S
• 通讯作者: Kojima S

Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan : Past, Present and Future

日本小儿白血病、骨髓衰竭和造血干细胞移植的进展：过去、现在和未来

• 发表时间: 2010
• 作者: Mastumoto M;Yasuda;K;Kubo M;Yoshimoto T;Nakanishi K.;Kojima S
• 通讯作者: Kojima S

Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia

• DOI: 10.1038/bmt.2009.378
• 发表时间: 2010-10-01
• 期刊: BONE MARROW TRANSPLANTATION
• 影响因子: 4.8
• 作者: Yagasaki, H.;Takahashi, Y.;Kojima, S.
• 通讯作者: Kojima, S.