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Association of regulatory T cells to etiology of children with aplastic anemia

Association of regulatory T cells to etiology of children with aplastic anemia
调节性 T 细胞与再生障碍性贫血儿童病因学的关联
批准号：
21390309
负责人：
KOJIMA Seiji
金额：
$8.82万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390309/
关键词：
Aplastic anemiaregulatory T cellantithymocyte globulin再生不良性貧血制御性T細胞抗ヒト胸腺グロブリンIL-10

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中文摘要
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英文摘要
We investigated the number of Tregs in children with alpastic anemia before and after IST or SCT. Fifty children with severe and very severe AA were enrolled in this study from 2007 to 2010. Surface CD4, CD25 and intracellular FOXP3 expression were examined in peripheral blood mononuclear cells by 3-color flow cytometry. The number of CD4+ CD25+ FOXP3+ Tregs is significantly decreased in patients at diagnosis as compared with normal control. The number of Tregs were significantly increased either after IST or after SCT.
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会议论文
Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis.
DOI： 10.1016/j.bbmt.2009.08.012
发表时间： 2009-12
期刊： Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子： --
作者： [H. Yagasaki;S. Kojima;H. Yabe;Koji Kato;H. Kigasawa;H. Sakamaki;M. Tsuchida;S. Kato;Takakaza Kawase;H. Muramatsu;Y. Morishima;Y. Kodera]
通讯作者： H. Yagasaki;S. Kojima;H. Yabe;Koji Kato;H. Kigasawa;H. Sakamaki;M. Tsuchida;S. Kato;Takakaza Kawase;H. Muramatsu;Y. Morishima;Y. Kodera
Pediatric AplasticAnemia-Immunosupressive Therapy
小儿再生障碍性贫血-免疫抑制治疗
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Takahashi S, Futatsugi-Yumikura S, Yoshimoto T, Yonehara S, Nakanishi K., Takahashi Y.]
通讯作者： Takahashi Y.
Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan
日本小儿白血病、骨髓衰竭和造血干细胞移植的进展
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Mizukami, H., Chaimongkol N, Kojima S]
通讯作者： Kojima S
Advances in Pediatric Leukemia, Bone Marrow Failure and Hematopoietic Stem Cell Transplantation in Japan : Past, Present and Future
日本小儿白血病、骨髓衰竭和造血干细胞移植的进展：过去、现在和未来
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Mastumoto M, Yasuda, K, Kubo M, Yoshimoto T, Nakanishi K., Kojima S]
通讯作者： Kojima S
共 65 条
    Studies on outer membrane stability and permeability of primitive chloroplasts and its evolutionary relationships between Gram-negative bacteria
    • 批准号：
      15K20860
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.58万
    • 财政年份：
      2015
    • 负责人：
      KOJIMA Seiji
    • 依托单位：
      Tohoku University
    Development of novel molecular targeted therapy for juvenile myelomonocytic leukemia
    • 批准号：
      24390262
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $8.57万
    • 财政年份：
      2012
    • 负责人：
      KOJIMA Seiji
    • 依托单位：
      Nagoya University
    Dynamic conformational changes that regulate the energy-converting unit
    • 批准号：
      24657087
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2012
    • 负责人：
      KOJIMA Seiji
    • 依托单位：
      Nagoya University
    Development of a new classification depend on epigenetic information in pediatric acquired bone marrow failure syndrome
    • 批准号：
      22659193
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $1.75万
    • 财政年份：
      2010
    • 负责人：
      KOJIMA Seiji
    • 依托单位：
      Nagoya University
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