Development of a new classification depend on epigenetic information in pediatric acquired bone marrow failure syndrome
新分类的开发取决于儿童获得性骨髓衰竭综合征的表观遗传信息
基本信息
- 批准号:22659193
- 负责人:
- 金额:$ 1.75万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The differential diagnosis between aplastic anemia(AA) and hypoplastic myelodysplastic syndrome(MDS), especially, refractory cytopenia of childhood(RCC) is still difficult. Six of 9 RCC specimens showed the TP53 gene mutation in TP53 positive stained cells cut by lazer microdissection system, however, there is no TP53 mutation in AA specimens. Furthermore, 2 of 5 RCC specimens showed the highly methylated status in the promotor region of p16 gene, but not in AA specimens. Higher expression of Evi-1, GATA-2 and AML1/RUNX1 were found than those at AA/MDS phase. We also found AML1/RUNX1 and N-RAS mutations occurred in this process.
再生障碍性贫血(AA)与骨髓增生异常综合征(MDS),特别是难治性儿童血细胞减少症(RCC)的鉴别诊断仍很困难。9例肾癌组织中6例经激光显微切割系统切取的TP 53阳性细胞中存在TP 53基因突变,而AA组织中未发现TP 53基因突变。5例肾细胞癌中有2例p16基因启动子区高度甲基化,而AA中未发现。Evi-1、加塔-2和AML 1/RUNX 1的表达均高于AA/MDS期。在此过程中还发现了AML 1/RUNX 1和N-RAS突变。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Recovery of dificient regulatory T cells after IST or SCT using ATG in children with aplastic anemia.
在患有再生障碍性贫血的儿童中使用 ATG 进行 IST 或 SCT 后缺乏的调节性 T 细胞的恢复。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:高橋義行;他
- 通讯作者:他
Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biological and Treatment Response Parameters : Conclusions of an International Working Group on Severe Aplastic Anemia Convened by the Blood and Marrow Transplant Clinical Trials Networ
基于临床、生物学和治疗反应参数优化严重再生障碍性贫血治疗:血液和骨髓移植临床试验网络召集的严重再生障碍性贫血国际工作组的结论
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Pulsipher MA;Kojima S(17人中8番目);et al.
- 通讯作者:et al.
Low-Dose Cytosine Arabinoside Therapy for Neonates with Down Syndrome (DS) and Transient Leukemia (TL)
低剂量胞嘧啶阿糖苷治疗新生儿唐氏综合症 (DS) 和暂时性白血病 (TL)
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Muramatsu H;et al.
- 通讯作者:et al.
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KOJIMA Seiji其他文献
Flagellar related genes and functions in <i>Vibrio</i>
弧菌中鞭毛相关基因和功能
- DOI:
10.3412/jsb.75.195 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
NISHIKINO Tatsuro;KOJIMA Seiji;HOMMA Michio - 通讯作者:
HOMMA Michio
KOJIMA Seiji的其他文献
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{{ truncateString('KOJIMA Seiji', 18)}}的其他基金
Studies on outer membrane stability and permeability of primitive chloroplasts and its evolutionary relationships between Gram-negative bacteria
原始叶绿体外膜稳定性、通透性及其与革兰氏阴性菌进化关系的研究
- 批准号:
15K20860 - 财政年份:2015
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of novel molecular targeted therapy for juvenile myelomonocytic leukemia
幼年型粒单核细胞白血病新型分子靶向治疗的开发
- 批准号:
24390262 - 财政年份:2012
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Dynamic conformational changes that regulate the energy-converting unit
调节能量转换单元的动态构象变化
- 批准号:
24657087 - 财政年份:2012
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Association of regulatory T cells to etiology of children with aplastic anemia
调节性 T 细胞与再生障碍性贫血儿童病因学的关联
- 批准号:
21390309 - 财政年份:2009
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mechanism of bone marrow failure in aplastic anemia -Role of mesenchymal stem cell-
再生障碍性贫血骨髓衰竭的机制-间充质干细胞的作用-
- 批准号:
19390283 - 财政年份:2007
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Biochemical analysis of the stator in the sodium-driven bacterial flagellar motor
钠驱动细菌鞭毛马达定子的生化分析
- 批准号:
18770129 - 财政年份:2006
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Terahertz dynamics of complex liquids
复杂液体的太赫兹动力学
- 批准号:
16204032 - 财政年份:2004
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Effect of G-CSF on hematopoietic stem cells derived from aplastic anemia patients in NOD/SCID/γc^<null> mice
G-CSF对NOD/SCID/γc^<null>小鼠再生障碍性贫血患者造血干细胞的影响
- 批准号:
15591103 - 财政年份:2003
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study of the mechanism of bone marrow failure in hepatitis-associated aplastic anemia.
肝炎相关再生障碍性贫血骨髓衰竭机制的研究。
- 批准号:
13670792 - 财政年份:2001
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Rapid acquisition of Brillouin spectra by non-scanning Fabry-Perot interferometer
通过非扫描法布里-珀罗干涉仪快速采集布里渊光谱
- 批准号:
11555019 - 财政年份:1999
- 资助金额:
$ 1.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
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Immune escape mechanisms in BCOR/BCORL1 mutant hematopoietic stem cells from patients with aplastic anemia
再生障碍性贫血患者 BCOR/BCORL1 突变型造血干细胞的免疫逃逸机制
- 批准号:
23K15297 - 财政年份:2023
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$ 1.75万 - 项目类别:
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A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation with Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients with Severe Aplastic Anemia
一项针对新诊断患有严重再生障碍性贫血的儿童和年轻成人患者进行非亲缘供体骨髓移植与免疫抑制治疗比较的 III 期随机试验
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10722602 - 财政年份:2022
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A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation with Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients with Severe Aplastic Anemia
一项针对新诊断患有严重再生障碍性贫血的儿童和年轻成人患者进行非亲缘供体骨髓移植与免疫抑制治疗比较的 III 期随机试验
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10676888 - 财政年份:2022
- 资助金额:
$ 1.75万 - 项目类别:
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1/2A III 期随机试验,比较无关供体骨髓移植与免疫抑制治疗对新诊断患有严重再生障碍性贫血的儿童和年轻成人患者的影响
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