课题基金 / 基金详情

Evolution of ovarian carcinoma cells through peritoneal dissemination ; genome-wide analysis and clinical application.

Evolution of ovarian carcinoma cells through peritoneal dissemination ; genome-wide analysis and clinical application.
卵巢癌细胞通过腹膜播散的进化；
批准号：
21390452
负责人：
KONISHI Ikuo
金额：
$11.32万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390452/
关键词：
婦人科腫瘍学卵巣癌播種性転移腫瘍免疫TGF-beta経路エピジェネティクスTGFβマイクロアレイメチル化低分子化合物

项目摘要

项目成果

KONISHI Ikuo的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
1) Treatment of 39 ovarian cancer cell lines and 17 primary culture samples with the inhibitor of DNA methylation, followed by expression microarray, identified genes targeted by DNA methylation in ovarian cancer. This analysis revealed TGF-beta signaling pathway is regulated by genome-wide DNA methylation. 2) We found TGF-beta pathway activity is upregulated in the omental metastases of ovarian cancer. Then we demonstrated the inhibitor of TGF-beta signaling pathway is effective against disseminated metastasis of ovarian cancer using a mouse model. 3) We found expression of PDL-1 in ovarian cancer cells suppresses activity of CD8 positive T lymphocytes, causes immune escape, and facilitates peritoneal dissemination of ovarian cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Clinical value of FDG-PET for preoperative evaluation of endometrial cancer
DOI： 10.1007/s12149-011-0474-2
发表时间： 2011-05-01
期刊： ANNALS OF NUCLEAR MEDICINE
影响因子： 2.6
作者： [Suga, Tsuyoshi, Nakamoto, Yuji, Togashi, Kaori]
通讯作者： Togashi, Kaori
The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors
DOI： 10.1016/j.clim.2011.08.013
发表时间： 2011-12-01
期刊： CLINICAL IMMUNOLOGY
影响因子： 8.6
作者： [Hamanishi, Junzo, Mandai, Masaki, Konishi, Ikuo]
通讯作者： Konishi, Ikuo
Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy
弥散性血管内凝血是妊娠期胃癌的表现
DOI： 10.1111/j.1447-0756.2011.01561.x
发表时间： 2011
期刊： J Obstet Gynaecol Res
影响因子： --
作者： [Takai H, Kondoh E, Sato Y, Kakui K, Tatsumi K, Konishi I.]
通讯作者： Konishi I.
Management of retained products of conception with marked vascularity
DOI： 10.1111/j.1447-0756.2010.01363.x
发表时间： 2011-05-01
期刊： JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
影响因子： 1.6
作者： [Kitahara, Tomoko, Sato, Yukiyasu, Konishi, Ikuo]
通讯作者： Konishi, Ikuo
共 26 条
    Develop of ovarian cancer stem cell specific immunotherapy based on DNA microarray analysis
    • 批准号：
      23659777
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2011
    • 负责人：
      KONISHI Ikuo
    • 依托单位：
      Kyoto University
    Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.
    • 批准号：
      19390426
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $12.15万
    • 财政年份：
      2007
    • 负责人：
      KONISHI Ikuo
    • 依托单位：
      Kyoto University
    Development of a new molecular target therapy for ovarian carcinoma based on the analyses of mechanisms for its peritoneal dissemination
    • 批准号：
      15390502
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.82万
    • 财政年份：
      2003
    • 负责人：
      KONISHI Ikuo
    • 依托单位：
      Shinshu University
    Molecular mechanisms of peritoneal dissemination of ovarian cancer cell, based on the analysis of its microenvironment
    • 批准号：
      13470349
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.22万
    • 财政年份：
      2001
    • 负责人：
      KONISHI Ikuo
    • 依托单位：
      SHINSHU UNIVERSITY
    海外基金