Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.
Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.
批准号:
19390426
负责人:
KONISHI Ikuo
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
卵巣癌の微小環境によるシグナル分子のエピジェネティックな変化に伴い、HIF-SNAIL-E-cadherin 経路、S100A4-RhoA 経路、Hedgehog 経路、さらにTGFβ経路の活性化が、卵巣癌細胞の播種性転移を促進させることを明らかとした。さらにRhoA、Hedgehog、TGFβの各シグナル経路を阻害する低分子化合物は、卵巣癌播種性転移の治療薬となりうることを明らかにした。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1016/j.ygyno.2007.02.005
发表时间:
2007-06-01
期刊:
GYNECOLOGIC ONCOLOGY
影响因子:
4.7
作者:
[Baba, Tsukasa, Kariya, Masatoshi, Fujii, Shingo]
通讯作者:
Fujii, Shingo
DOI:
10.1200/jco.2006.08.8344
发表时间:
2007-07-01
期刊:
JOURNAL OF CLINICAL ONCOLOGY
影响因子:
45.3
作者:
[Ushijima, Kimio, Yahata, Hideaki, Kamura, Toshiharu]
通讯作者:
Kamura, Toshiharu
Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period
卵巢成熟囊性畸胎瘤恶变,包括随访期间发生的三例
DOI:
--
发表时间:
2008
期刊:
Oncol Rep 19
影响因子:
--
作者:
[Yamaguchi K, Mandai M, Fukuhara K, Higuchi T, Hamanishi J, Takakura K, Fujii S.]
通讯作者:
Fujii S.
DOI:
10.1016/j.bbrc.2007.06.070
发表时间:
2007-08-24
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Baba, Tsukasa, Mori, Seiichi, Fujii, Shingo]
通讯作者:
Fujii, Shingo
卵巣癌の発生および進展のエピジェネティクス解析-BRCA1メチル化およびS100A4脱メチル化の臨床的意義
卵巢癌发生和进展的表观遗传学分析——BRCA1甲基化和S100A4去甲基化的临床意义
DOI:
--
发表时间:
2008
期刊:
日本産科婦人科学会雑誌 60
影响因子:
--
作者:
[Kashima H, Horiuchi A, Uchikawa J, Miyamoto T, Suzuki A, Ashida T, Konishi I, Shiozawa T, 堀内晶子]
通讯作者:
堀内晶子
共 29 条
Develop of ovarian cancer stem cell specific immunotherapy based on DNA microarray analysis
-
批准号:23659777
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:KONISHI Ikuo
-
依托单位:
Evolution of ovarian carcinoma cells through peritoneal dissemination ; genome-wide analysis and clinical application.
-
批准号:21390452
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2009
-
负责人:KONISHI Ikuo
-
依托单位:
Development of a new molecular target therapy for ovarian carcinoma based on the analyses of mechanisms for its peritoneal dissemination
-
批准号:15390502
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.82万
-
财政年份:2003
-
负责人:KONISHI Ikuo
-
依托单位:
Molecular mechanisms of peritoneal dissemination of ovarian cancer cell, based on the analysis of its microenvironment
-
批准号:13470349
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.22万
-
财政年份:2001
-
负责人:KONISHI Ikuo
-
依托单位:
Development of novel gene therapy based on the analysis of anti-apoptotic signals in ovarian cancer
-
批准号:11470347
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$9.47万
-
财政年份:1999
-
负责人:KONISHI Ikuo
-
依托单位:
Clinicopathological and Molecular Analyses for Possible Correlation between Infertility Therapy and Development of Ocarian Cancer
-
批准号:09470358
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.85万
-
财政年份:1997
-
负责人:KONISHI Ikuo
-
依托单位:
Molecular-pathologic and clinicopathologic study on the heterogeneity of early development and progression of ovarian cancer
-
批准号:07457608
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$0.96万
-
财政年份:1995
-
负责人:KONISHI Ikuo
-
依托单位:
Role of Heat Shock Proteins in Physiology and Pathology of the Female Genital Tract
-
批准号:05454447
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.42万
-
财政年份:1993
-
负责人:KONISHI Ikuo
-
依托单位:
Study on pathogenesis of endometrial carcinomas based on the analysis of growth and differentiation of endometrial gland
-
批准号:03670781
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1991
-
负责人:KONISHI Ikuo
-
依托单位:
海外基金