Analysis of signaling pathways in peritoneal dissemination of ovarian cancer, which leads to investigation for their suppressor reagents.

分析卵巢癌腹膜传播的信号通路，从而研究其抑制试剂。

• 批准号: 19390426
• 负责人: KONISHI Ikuo
• 金额: $ 12.15万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390426/
• 关键词: 卵巣癌; 播種性転移; エピジェネティックス; シグナル伝達; マイクロアレイ; 低分子化合物; メチル化; TGFβ; S100A4; Snail; RhoA; E-cadherin; Hedgehog

卵巣癌の微小環境によるシグナル分子のエピジェネティックな変化に伴い、HIF-SNAIL-E-cadherin 経路、S100A4-RhoA 経路、Hedgehog 経路、さらにTGFβ経路の活性化が、卵巣癌細胞の播種性転移を促進させることを明らかとした。さらにRhoA、Hedgehog、TGFβの各シグナル経路を阻害する低分子化合物は、卵巣癌播種性転移の治療薬となりうることを明らかにした。

In the microenvironment of ovarian cancer, the activation of TGFβ pathway, HIF-SNAIL-E-cadherin pathway, S100A4-RhoA pathway, Hedgehog pathway, and the promotion of seeding migration of ovarian cancer cells are discussed. Low molecular weight compounds that block the pathway of RhoA, Hedgehog, and TGFβ are now known to be therapeutic agents for ovarian cancer seeding.

项目成果

Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition

• DOI: 10.1016/j.ygyno.2007.02.005
• 发表时间: 2007-06-01
• 期刊: GYNECOLOGIC ONCOLOGY
• 影响因子: 4.7
• 作者: Baba, Tsukasa;Kariya, Masatoshi;Fujii, Shingo
• 通讯作者: Fujii, Shingo

Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women

• DOI: 10.1200/jco.2006.08.8344
• 发表时间: 2007-07-01
• 期刊: JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 45.3
• 作者: Ushijima, Kimio;Yahata, Hideaki;Kamura, Toshiharu
• 通讯作者: Kamura, Toshiharu

Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period

卵巢成熟囊性畸胎瘤恶变，包括随访期间发生的三例

• 发表时间: 2008
• 期刊: Oncol Rep 19
• 作者: Yamaguchi K;Mandai M;Fukuhara K;Higuchi T;Hamanishi J;Takakura K;Fujii S.
• 通讯作者: Fujii S.

Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity

• DOI: 10.1016/j.bbrc.2007.06.070
• 发表时间: 2007-08-24
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Baba, Tsukasa;Mori, Seiichi;Fujii, Shingo
• 通讯作者: Fujii, Shingo

Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells

• DOI: 10.1158/1078-0432.ccr-06-1407
• 发表时间: 2007-03-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Feng, Yu-Zhen;Shiozawa, Tanri;Konishi, Ikuo
• 通讯作者: Konishi, Ikuo