Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule

血栓调节蛋白（TM）是一种内皮细胞表面膜蛋白，含有一个大的细胞外区域，该区域含有凝血酶结合位点。TM也在其他组织中表达，这表明它被认为具有多种功能。事实上，与凝血酶结合的TM在诸如高迁移率族蛋白-1（HMGB 1）降解的环境中的炎症反应的减弱中起重要作用。本研究的目的是探讨是否存在新的TM结合蛋白。本研究表明TM可能与HistonH 3结合。

Thrombomodulin(TM) is an endothelial cell surface membrane protein and contains a large extracellular region that harbors a thrombin-binding site. TM is also expressed in other tissues, suggesting that it is thought to perform various functions. Indeed, TM, which is bound to thrombin, plays an important role in the attenuation of the inflammatory response in settings such as High mobility group box-1 protein(HMGB1) degradation. The aims of present study are whether the novel TM-binding protein exists. This study demonstrates that TM might bind to HistonH3.