Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule

开发血栓调节蛋白作为平台型分子的新型抗炎作用

• 批准号: 21390483
• 负责人: KAWAHARA Ko-ichi
• 金额: $ 10.73万
• 依托单位: Osaka Institute of Technology (2011)Kagoshima University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390483/
• 关键词: 集中治療医学; トロンボモジュリン; 炎症; ヒストン; プラットフォーム分子; thrombomodulin; 補体

Thrombomodulin(TM) is an endothelial cell surface membrane protein and contains a large extracellular region that harbors a thrombin-binding site. TM is also expressed in other tissues, suggesting that it is thought to perform various functions. Indeed, TM, which is bound to thrombin, plays an important role in the attenuation of the inflammatory response in settings such as High mobility group box-1 protein(HMGB1) degradation. The aims of present study are whether the novel TM-binding protein exists. This study demonstrates that TM might bind to HistonH3.

血栓调节蛋白（TM）是一种内皮细胞表面膜蛋白，含有一个大的细胞外区域，该区域含有凝血酶结合位点。TM也在其他组织中表达，这表明它被认为具有多种功能。事实上，与凝血酶结合的TM在诸如高迁移率族蛋白-1（HMGB 1）降解的环境中的炎症反应的减弱中起重要作用。本研究的目的是探讨是否存在新的TM结合蛋白。本研究表明TM可能与HistonH 3结合。

项目成果

Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease

粒细胞和单核细胞吸附分离术作为 Reiter 病的有​​效治疗方法

• 发表时间: 2012
• 期刊: Clin Exp Dermatol
• 影响因子: 4.1
• 作者: Yoshifuku A;Oyama K;Ibusuki A;Kawasaki M;Sakanoue M;Matsushita S;Kawai K;Kawahara K;Maruyama I;Kanekura T
• 通讯作者: Kanekura T

High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.

• DOI: 10.1038/labinvest.2010.64
• 发表时间: 2010-06
• 期刊: Laboratory investigation; a journal of technical methods and pathology

Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4

• DOI: 10.1016/j.bbrc.2009.09.015
• 发表时间: 2009-12-25
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kikuchi, Kiyoshi;Tancharoen, Salunya;Kawahara, Ko-ichi
• 通讯作者: Kawahara, Ko-ichi

The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells

• DOI: 10.1124/jpet.108.149484
• 发表时间: 2009-06-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Kikuchi, Kiyoshi;Kawahara, Ko-ichi;Maruyama, Ikuro
• 通讯作者: Maruyama, Ikuro

Immunohistochemical expression of thrombomodulin in vestibular schwannoma

前庭神经鞘瘤中血栓调节蛋白的免疫组织化学表达

• 发表时间: 2012
• 期刊: Brain Tumor Pathol
• 影响因子: 3.3
• 作者: Yamahata H;Yunoue S;Tokimura H;Hanaya R;Hirano H;Tokudome M;Karki P;Yonezawa H;Sugata S;Kawahara KI;Maruyama I;Arita K
• 通讯作者: Arita K