Nucleophosmin: immunoactivity as a novel alarmin

核磷蛋白是一种主要的核仁多功能蛋白，参与核糖体的生物发生、中心体复制、细胞周期进展、细胞凋亡和细胞分化。警报是从激活的细胞和/或死亡的细胞中释放的内源性分子，它激活免疫系统，对细胞和组织器官造成严重损害。最近，核磷蛋白从内毒素刺激的RAW264.7细胞中释放出来，并诱导细胞因子，提示核磷蛋白可能是一种警报蛋白。然而，核磷蛋白作为一种警报蛋白仍不清楚。在这项研究中，我们发现核磷蛋白刺激的RAW264.7细胞的吞噬功能显著增强。此外，核磷蛋白以剂量依赖的方式增强吞噬功能。我们的发现表明，核磷脂可能是一种危言耸听的东西。

Nucleophosmin is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Alarmins are endogenous molecules released from activated cells and/or dying cells, which activate the immune system and cause severe damage to cells and tissue organs. Recently, the nucleophosmin is released from endotoxin-stimulated RAW264.7 cells and induces cytokines, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin as a alarmin remains unclear. In this study, we found that the nucleophosmin-stimulated RAW264.7 cells significantly enhanced phagocytosis with flowcytometry. Furthermore, the nuclephosmin enhanced phagocytosis in in a dose-dependent fashion. Our findings suggest that nucleophosmin may be an alarmin.