Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
批准号:
22390120
负责人:
ICHIHARA Gaku
金额:
$12.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Exposure to 1-bromopropane (1BP) induced oxidative stress as well as activating astrocyte and microglia in the cerebellum of rats. Exposure to 1BP also promoted carbonylation of various proteins including triosephosphateisomerase (TPI), decreased TPI activity and increased advanced glycation endproduct. The study suggested oxidative stress might be involved in toxicity of 1BP to the central nervous system.
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DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara]
通讯作者:
Sahoko Ichihara
Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane
1-溴丙烷暴露的 F344 大鼠海马蛋白的蛋白质组学分析
DOI:
--
发表时间:
期刊:
Toxicology and Applied Pharmacology
影响因子:
3.8
作者:
[Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Masahide Takahashi, Kaviarasan Subramanian]
通讯作者:
Kaviarasan Subramanian
Susceptibility to 1-bromopropane exposure and gene expression in two rat strains
两种大鼠品系对 1-溴丙烷暴露的敏感性和基因表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Gaku Ichihara, 他7名]
通讯作者:
他7名
オーストラリア鉱山における1-プロモプロパン中毒事例
澳大利亚矿井发生1-丙丙烷中毒事件
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shigeki Moriguchi, Satomi Kita, Issei Komuro. Takahiro Iwamoto and Kohji Fukunaga, 市原学]
通讯作者:
市原学
nrf2ノックアウトマウスは1-プロモプロパン曝露に対し感受性が高い
nrf2 敲除小鼠对 1-丙丙烷暴露敏感
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[劉芳, 市原佐保子, Sahabudeen Sheik Mohideen, 伊東健, 山本雅之, Wiliam M.Valentine, 鬼頭純三, 市原学]
通讯作者:
市原学
共 111 条
Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
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批准号:24406018
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2012
-
负责人:ICHIHARA Gaku
-
依托单位:
Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
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批准号:23659326
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2011
-
负责人:ICHIHARA Gaku
-
依托单位:
Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
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批准号:21406017
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2009
-
负责人:ICHIHARA Gaku
-
依托单位:
Analysis of molecular and cellular targets in neurotoxicity of alternatives to ozone-depleting substances and establishment of biomarkers for the central nervous toxicity
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批准号:19390160
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
-
财政年份:2007
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负责人:ICHIHARA Gaku
-
依托单位:
Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans
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批准号:17406017
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.77万
-
财政年份:2005
-
负责人:ICHIHARA Gaku
-
依托单位:
Investigation on protein adduct produced by alternatives to ozone-depleting substances and susceptibility genes and establishment of new method for risk assessment.
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批准号:16390169
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
-
财政年份:2004
-
负责人:ICHIHARA Gaku
-
依托单位:
Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility
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批准号:14406015
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.28万
-
财政年份:2002
-
负责人:ICHIHARA Gaku
-
依托单位:
INVESTIGATION ON TOXICITIES OF ALTERNATIVES FOR CHLOROFLUOROCARBONS AND ITS RISK ASSESSMENT USING MOLECULAR AND BIOLOGICAL MARKERS.
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批准号:13470088
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.28万
-
财政年份:2001
-
负责人:ICHIHARA Gaku
-
依托单位:
Development Deregulating system for inhalation exposure to volatile organic chemicals (VOCs) for toxicity testing
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批准号:12557039
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.62万
-
财政年份:2000
-
负责人:ICHIHARA Gaku
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依托单位:
Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
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批准号:11670367
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:ICHIHARA Gaku
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依托单位:
海外基金