Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
批准号:
23659326
负责人:
ICHIHARA Gaku
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
The present study revealed that exposure to 1-bromopropane, an alternative to ozone-depleting solvents, suppressed neurogenesis in the dentate gyrus of adult rats and noradrenaline, glucocorticoid receptor (GR), brain-derived neurotropic factor (BDNF) are expected to be involved in suppression of the neurogenesis. Change in serotonin level was minimal compared to the decrease in noradrenaline level. Count of proliferative cell in the dentate gyrus, and the level of noradrenaline, GR or BDNF may be used as biomarkers for the toxicity of 1-bromopropane to the central nervous system.
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中皮腫患者の肺内石綿・非石綿繊維量とその表面積
间皮瘤患者肺部石棉和非石棉纤维的含量及其表面积
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[酒井潔, 久永直見, 柴田英治, 上島通浩, 内藤久雄, 市原学, 那須民江]
通讯作者:
那須民江
Exposure to 1-bromopropane decreases neuron proliferation in adult rat dentate gyrus
暴露于 1-溴丙烷会降低成年大鼠齿状回的神经元增殖
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Lingyi ZHANG, Taku NAGAI, Kiyofumi YAMADA, Sahoko ICHIHARA, Kaviarasan SUBURAMANIAN, Zhenlie HUANG, Sahabudeen Sheik MOHIDEEN, Hisao NAITO, Gaku ICHIHARA]
通讯作者:
Gaku ICHIHARA
1-bromopropane increases triosephosphate isomerase carbonylation and advanced glycation end-products in the hippocampus of F344 rats
1-溴丙烷增加 F344 大鼠海马中磷酸三糖异构酶的羰基化和晚期糖基化终产物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Zhenlie HUANG, Sahoko ICHIHARA, Shinji OIKAWA, Jie CHANG, Lingyi ZHANG, Kaviarasan SUBRAMANIAN, Sahabudeen Sheik MOHIDEEN, Gaku ICHIHARA]
通讯作者:
Gaku ICHIHARA
Effects of Exposure to 1‐Bromopropane on Astrocytes and Oligodendrocytes in Rat Brain
暴露于 1-溴丙烷对大鼠脑中星形胶质细胞和少突胶质细胞的影响
DOI:
10.1539/joh.12-0118-oa
发表时间:
2013
期刊:
Journal of Occupational Health
影响因子:
3
作者:
[S. Mohideen, S. Ichihara, K. Subramanian, Zhenlie Huang, Hisao Naito, J. Kitoh, G. Ichihara]
通讯作者:
G. Ichihara
DOI:
10.1001/archinternmed.2012.3987
发表时间:
2012-09
期刊:
Archives of internal medicine
影响因子:
--
作者:
[M. Samukawa;G. Ichihara;N. Oka;S. Kusunoki]
通讯作者:
M. Samukawa;G. Ichihara;N. Oka;S. Kusunoki
共 62 条
Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
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批准号:24406018
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
-
财政年份:2012
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负责人:ICHIHARA Gaku
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依托单位:
Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
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批准号:22390120
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.56万
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财政年份:2010
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负责人:ICHIHARA Gaku
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依托单位:
Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
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批准号:21406017
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.23万
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财政年份:2009
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负责人:ICHIHARA Gaku
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依托单位:
Analysis of molecular and cellular targets in neurotoxicity of alternatives to ozone-depleting substances and establishment of biomarkers for the central nervous toxicity
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批准号:19390160
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:ICHIHARA Gaku
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依托单位:
Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans
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批准号:17406017
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.77万
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财政年份:2005
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负责人:ICHIHARA Gaku
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依托单位:
Investigation on protein adduct produced by alternatives to ozone-depleting substances and susceptibility genes and establishment of new method for risk assessment.
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批准号:16390169
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2004
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负责人:ICHIHARA Gaku
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依托单位:
Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility
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批准号:14406015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2002
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负责人:ICHIHARA Gaku
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依托单位:
INVESTIGATION ON TOXICITIES OF ALTERNATIVES FOR CHLOROFLUOROCARBONS AND ITS RISK ASSESSMENT USING MOLECULAR AND BIOLOGICAL MARKERS.
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批准号:13470088
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2001
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负责人:ICHIHARA Gaku
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依托单位:
Development Deregulating system for inhalation exposure to volatile organic chemicals (VOCs) for toxicity testing
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批准号:12557039
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.62万
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财政年份:2000
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负责人:ICHIHARA Gaku
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依托单位:
Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
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批准号:11670367
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:ICHIHARA Gaku
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依托单位:
海外基金