Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system

神经发生在环境化学物质对中枢神经系统慢性或迟发型毒性机制中的作用

• 批准号: 23659326
• 负责人: ICHIHARA Gaku
• 金额: $ 2.41万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659326/
• 关键词: バイオマーカー; リスク評価; ブロモプロパン; ニューロン新生; 神経新生; 環境化学物質; 抑うつ; 認知機能

The present study revealed that exposure to 1-bromopropane, an alternative to ozone-depleting solvents, suppressed neurogenesis in the dentate gyrus of adult rats and noradrenaline, glucocorticoid receptor (GR), brain-derived neurotropic factor (BDNF) are expected to be involved in suppression of the neurogenesis. Change in serotonin level was minimal compared to the decrease in noradrenaline level. Count of proliferative cell in the dentate gyrus, and the level of noradrenaline, GR or BDNF may be used as biomarkers for the toxicity of 1-bromopropane to the central nervous system.

目前的研究表明，暴露于1-溴丙烷，臭氧消耗溶剂的替代品，抑制成年大鼠的齿状回的神经发生和去甲肾上腺素，糖皮质激素受体（GR），脑源性神经营养因子（BDNF）可能参与抑制的神经发生。与去甲肾上腺素水平下降相比，5-羟色胺水平变化极小。齿状回增殖细胞计数、去甲肾上腺素、GR和BDNF水平可作为1-溴丙烷中枢毒性的生物标志物。

项目成果

1-bromopropane increases triosephosphate isomerase carbonylation and advanced glycation end-products in the hippocampus of F344 rats

1-溴丙烷增加 F344 大鼠海马中磷酸三糖异构酶的羰基化和晚期糖基化终产物

• 发表时间: 2012
• 作者: Zhenlie HUANG;Sahoko ICHIHARA;Shinji OIKAWA;Jie CHANG;Lingyi ZHANG;Kaviarasan SUBRAMANIAN;Sahabudeen Sheik MOHIDEEN;Gaku ICHIHARA
• 通讯作者: Gaku ICHIHARA

Exposure to 1-bromopropane decreases neuron proliferation in adult rat dentate gyrus

暴露于 1-溴丙烷会降低成年大鼠齿状回的神经元增殖

• 发表时间: 2012
• 作者: Lingyi ZHANG;Taku NAGAI;Kiyofumi YAMADA;Sahoko ICHIHARA;Kaviarasan SUBURAMANIAN;Zhenlie HUANG;Sahabudeen Sheik MOHIDEEN;Hisao NAITO;Gaku ICHIHARA
• 通讯作者: Gaku ICHIHARA

Effects of Exposure to 1‐Bromopropane on Astrocytes and Oligodendrocytes in Rat Brain

暴露于 1-溴丙烷对大鼠脑中星形胶质细胞和少突胶质细胞的影响

• DOI: 10.1539/joh.12-0118-oa
• 发表时间: 2013
• 期刊: Journal of Occupational Health
• 影响因子: 3
• 作者: S. Mohideen;S. Ichihara;K. Subramanian;Zhenlie Huang;Hisao Naito;J. Kitoh;G. Ichihara
• 通讯作者: G. Ichihara

中皮腫患者の肺内石綿・非石綿繊維量とその表面積

间皮瘤患者肺部石棉和非石棉纤维的含量及其表面积

• 作者: 酒井潔;久永直見;柴田英治;上島通浩;内藤久雄;市原学;那須民江
• 通讯作者: 那須民江

A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents.

• DOI: 10.1001/archinternmed.2012.3987
• 发表时间: 2012-09
• 期刊: Archives of internal medicine
• 作者: M. Samukawa;G. Ichihara;N. Oka;S. Kusunoki