Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility
1-溴丙烷所致神经异常及个体易感性差异的研究
基本信息
- 批准号:14406015
- 负责人:
- 金额:$ 9.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2002
- 资助国家:日本
- 起止时间:2002 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1)Analysis on the cases intoxicated with 1-bromopropane in North Carolina in United States of America.The worker (A)working in a cushion factory in United States used an adhesive containing mainly 1-bromopropane as solvent. Decrease in vibration sense, anesthesia such as burning sensation, numbness in buttocks, frontal thighs, lower things and foot, and stumbling were found in the worker. The symptoms suggesting disorder in the central nervous system such as irritation, depression and headache were also observed. Colleagues (B)and (C)of this worker showed also similar symptoms to the above. As the workers (A)and (B)left the workplace at the investigation, we evaluated an individual exposure level for the worker (C)with passive samplers. The exposure level was 60 to 261,averaged 133 ppm.2)Investigation on neurologic disorders in the workers in 1-bromopropane factories in Jiangsu Province in China.The comparison of twenty-three workers exposed to 1-bromopropane after matching with age and sex showed elongation in distal latency in lower limbs as well as lower scores in neurobehavioral testing. Fifteen workers among the exposed showed decrease in vibration sense clearly.3)Evaluation of individual exposure levels, metabolites and nerve conduction velocities. The individual variations were assessed with them. Urinary metabolites, N-acetyl-S-propylcysteine were investigated in workers exposed to 1-bromopropane. The examined indices such as nerve conduction velocity did not show any clear dose-response relationship among workers. It suggested (1)passive samplers and urinary metabolites did show only short-term exposure that is not associated with long-term exposure to 1-bromopropane and (2)possible difference in individual variations in susceptibilities. Further investigation is required to address this issue.
1)美国北卡罗来纳州1-溴丙烷中毒案例分析美国一家垫子厂的工人(A)使用一种主要含有1-溴丙烷的粘合剂作为溶剂。振动感降低,有灼热感、臀部麻木、大腿前部麻木、下物和足部麻木、绊倒等。还观察了刺激、抑郁和头痛等提示中枢神经系统紊乱的症状。这名工人的同事(B)和(C)也表现出与上述类似的症状。当工人(A)和(B)在调查时离开工作场所时,我们用被动采样器评估了工人(C)的个人接触水平。2)江苏省1-溴丙烷作业工人神经功能障碍调查,23名接触1-溴丙烷作业工人与年龄、性别匹配后比较,肢体远端潜伏期延长,神经行为测试得分降低。3)个体接触水平、代谢物和神经传导速度的评价。用它们对个体变异进行评估。对1-溴丙烷作业工人尿液代谢产物N-乙酰-S-丙基半胱氨酸进行了研究。所检测的神经传导速度等指标在作业工人中未显示出明显的剂量-反应关系。这表明(1)被动采样器和尿液代谢物确实只显示出与长期接触1-溴丙烷无关的短期接触,以及(2)个体易感性的差异。为了解决这个问题,需要进行进一步的调查。
项目成果
期刊论文数量(86)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Toxicology-fundamental, clinics and social medicine
毒理学基础、临床和社会医学
- DOI:
- 发表时间:2002
- 期刊:
- 影响因子:0
- 作者:Takeuchi Y. et al.
- 通讯作者:Takeuchi Y. et al.
A survey of semen indices in insecticide sprayers
- DOI:10.1539/joh.46.109
- 发表时间:2004-03-01
- 期刊:
- 影响因子:3
- 作者:Kamijima, M;Hibi, H;Takeuchi, Y
- 通讯作者:Takeuchi, Y
Serial alterations of beta-adrenergic signaling in dilated cardiomyopathic hamsters : possible role of myocardial oxidative stress.
扩张型心肌病仓鼠中β-肾上腺素能信号的连续改变:心肌氧化应激的可能作用。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Nishizawa T. et al.
- 通讯作者:Nishizawa T. et al.
Yamada T.et al.: "Exposure to 1-bromopropane caused ovarian dysfunction in rats."Toxicological Sciences. 71. 96-103 (2003)
Yamada T.et al.:“暴露于 1-溴丙烷导致大鼠卵巢功能障碍。”毒理学科学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
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ICHIHARA Gaku其他文献
ICHIHARA Gaku的其他文献
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{{ truncateString('ICHIHARA Gaku', 18)}}的其他基金
Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
使用新生物标志物研究 1-溴丙烷的神经退行性作用
- 批准号:
24406018 - 财政年份:2012
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
神经发生在环境化学物质对中枢神经系统慢性或迟发型毒性机制中的作用
- 批准号:
23659326 - 财政年份:2011
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
氧化应激和神经胶质激活研究解释氟利昂替代品引起的中枢神经系统脱髓鞘
- 批准号:
22390120 - 财政年份:2010
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
1-溴丙烷对人体中枢神经系统和造血功能的毒性研究
- 批准号:
21406017 - 财政年份:2009
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of molecular and cellular targets in neurotoxicity of alternatives to ozone-depleting substances and establishment of biomarkers for the central nervous toxicity
分析臭氧消耗物质替代品神经毒性的分子和细胞靶标并建立中枢神经毒性生物标志物
- 批准号:
19390160 - 财政年份:2007
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans
1-溴丙烷对人体中枢神经系统毒性的剂量依赖性研究
- 批准号:
17406017 - 财政年份:2005
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Investigation on protein adduct produced by alternatives to ozone-depleting substances and susceptibility genes and establishment of new method for risk assessment.
消耗臭氧层物质替代品与易感基因产生的蛋白质加合物的调查及风险评估新方法的建立。
- 批准号:
16390169 - 财政年份:2004
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
INVESTIGATION ON TOXICITIES OF ALTERNATIVES FOR CHLOROFLUOROCARBONS AND ITS RISK ASSESSMENT USING MOLECULAR AND BIOLOGICAL MARKERS.
氯氟碳替代品的毒性调查及其使用分子和生物标记物的风险评估。
- 批准号:
13470088 - 财政年份:2001
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development Deregulating system for inhalation exposure to volatile organic chemicals (VOCs) for toxicity testing
开发用于毒性测试的挥发性有机化学品 (VOC) 吸入暴露放松管制系统
- 批准号:
12557039 - 财政年份:2000
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
氯氟烃新替代品1-溴丙烷生殖毒性和神经毒性机制研究
- 批准号:
11670367 - 财政年份:1999
- 资助金额:
$ 9.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)