Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility

1)美国北卡罗来纳州1-溴丙烷中毒案例分析美国一家垫子厂的工人(A)使用一种主要含有1-溴丙烷的粘合剂作为溶剂。振动感降低，有灼热感、臀部麻木、大腿前部麻木、下物和足部麻木、绊倒等。还观察了刺激、抑郁和头痛等提示中枢神经系统紊乱的症状。这名工人的同事(B)和(C)也表现出与上述类似的症状。当工人(A)和(B)在调查时离开工作场所时，我们用被动采样器评估了工人(C)的个人接触水平。2)江苏省1-溴丙烷作业工人神经功能障碍调查，23名接触1-溴丙烷作业工人与年龄、性别匹配后比较，肢体远端潜伏期延长，神经行为测试得分降低。3)个体接触水平、代谢物和神经传导速度的评价。用它们对个体变异进行评估。对1-溴丙烷作业工人尿液代谢产物N-乙酰-S-丙基半胱氨酸进行了研究。所检测的神经传导速度等指标在作业工人中未显示出明显的剂量-反应关系。这表明(1)被动采样器和尿液代谢物确实只显示出与长期接触1-溴丙烷无关的短期接触，以及(2)个体易感性的差异。为了解决这个问题，需要进行进一步的调查。

1)Analysis on the cases intoxicated with 1-bromopropane in North Carolina in United States of America.The worker (A)working in a cushion factory in United States used an adhesive containing mainly 1-bromopropane as solvent. Decrease in vibration sense, anesthesia such as burning sensation, numbness in buttocks, frontal thighs, lower things and foot, and stumbling were found in the worker. The symptoms suggesting disorder in the central nervous system such as irritation, depression and headache were also observed. Colleagues (B)and (C)of this worker showed also similar symptoms to the above. As the workers (A)and (B)left the workplace at the investigation, we evaluated an individual exposure level for the worker (C)with passive samplers. The exposure level was 60 to 261,averaged 133 ppm.2)Investigation on neurologic disorders in the workers in 1-bromopropane factories in Jiangsu Province in China.The comparison of twenty-three workers exposed to 1-bromopropane after matching with age and sex showed elongation in distal latency in lower limbs as well as lower scores in neurobehavioral testing. Fifteen workers among the exposed showed decrease in vibration sense clearly.3)Evaluation of individual exposure levels, metabolites and nerve conduction velocities. The individual variations were assessed with them. Urinary metabolites, N-acetyl-S-propylcysteine were investigated in workers exposed to 1-bromopropane. The examined indices such as nerve conduction velocity did not show any clear dose-response relationship among workers. It suggested (1)passive samplers and urinary metabolites did show only short-term exposure that is not associated with long-term exposure to 1-bromopropane and (2)possible difference in individual variations in susceptibilities. Further investigation is required to address this issue.