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Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility

1-溴丙烷所致神经异常及个体易感性差异的研究

基本信息

批准号：
14406015
负责人：
ICHIHARA Gaku
金额：
$ 9.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

1)Analysis on the cases intoxicated with 1-bromopropane in North Carolina in United States of America.The worker (A)working in a cushion factory in United States used an adhesive containing mainly 1-bromopropane as solvent. Decrease in vibration sense, anesthesia such as burning sensation, numbness in buttocks, frontal thighs, lower things and foot, and stumbling were found in the worker. The symptoms suggesting disorder in the central nervous system such as irritation, depression and headache were also observed. Colleagues (B)and (C)of this worker showed also similar symptoms to the above. As the workers (A)and (B)left the workplace at the investigation, we evaluated an individual exposure level for the worker (C)with passive samplers. The exposure level was 60 to 261,averaged 133 ppm.2)Investigation on neurologic disorders in the workers in 1-bromopropane factories in Jiangsu Province in China.The comparison of twenty-three workers exposed to 1-bromopropane after matching with age and sex showed elongation in distal latency in lower limbs as well as lower scores in neurobehavioral testing. Fifteen workers among the exposed showed decrease in vibration sense clearly.3)Evaluation of individual exposure levels, metabolites and nerve conduction velocities. The individual variations were assessed with them. Urinary metabolites, N-acetyl-S-propylcysteine were investigated in workers exposed to 1-bromopropane. The examined indices such as nerve conduction velocity did not show any clear dose-response relationship among workers. It suggested (1)passive samplers and urinary metabolites did show only short-term exposure that is not associated with long-term exposure to 1-bromopropane and (2)possible difference in individual variations in susceptibilities. Further investigation is required to address this issue.

1)美国北卡罗来纳州1-溴丙烷中毒病例分析美国一家座垫厂的工人（A）使用主要含1-溴丙烷的粘合剂作为溶剂。在工人中发现振动感下降，麻醉如烧灼感，臀部、大腿前部、下部物体和脚麻木，以及绊倒。还观察到提示中枢神经系统紊乱的症状，如刺激、抑郁和头痛。该工人的同事（B）和（C）也表现出与上述相似的症状。当工人（A）和（B）在调查时离开工作场所时，我们用被动采样器评估了工人（C）的个人暴露水平。接触水平为60 ~ 261 ppm，平均133 ppm。2）江苏省1-溴丙烷厂工人神经系统疾病调查：对23名1-溴丙烷接触工人进行年龄、性别配对比较，发现其下肢远端潜伏期延长，神经行为测试得分降低。15名接触者振动觉明显减退。3）个体暴露水平、代谢物和神经传导速度评价。用它们评估个体差异。本文研究了接触1-溴丙烷工人尿中N-乙酰-S-丙基半胱氨酸的代谢产物。神经传导速度等检测指标在工人中未显示出明显的剂量-反应关系。这表明：（1）被动采样器和尿液代谢物仅显示短期接触，与长期接触1-溴丙烷无关;（2）敏感性的个体差异可能存在差异。需要进一步调查以解决该问题。