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Effects of proteases on differentiation and maturation of oligodendrocytes

Effects of proteases on differentiation and maturation of oligodendrocytes
蛋白酶对少突胶质细胞分化成熟的影响
批准号:
21500322
负责人:
YOSHIDA Shigetaka
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
KLK6 is a serine protease specifically expressed in oligodendrocytes. The function of the protease on the maturation of oligodendrocyte has been undetermined. We analyzed KLK6 gene knockout (KLK6-KO) mice and found that the development of oligodendrocytes was temporally delayed. We also found that the expression of myelin basic protein was smaller in KLK6-KO mice than that of wild-type mice. These results indicate that KLK6 plays a role in the development of oligodendrocytes.
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会议论文
Morphological changes of axons and myelin in experimental autoimmune encephalomyelitis
实验性自身免疫性脑脊髓炎轴突和髓磷脂的形态变化
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [BandoY, Nomura T, Bochimoto H, Kouga D, Watanabe T, Yoshida S]
通讯作者: Yoshida S
DOI: 10.1515/bc.2010.034
发表时间: 2010-04
期刊:
影响因子: --
作者: [S. Yoshida]
通讯作者: S. Yoshida
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [村上公一, 板東良雄, 吉田成孝]
通讯作者: 吉田成孝
マウス多発性硬化症モデルにおけるKLK6を介した脱髄分子機所
KLK6介导的小鼠多发性硬化症模型脱髓鞘的分子机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [板東良雄, 村上公一, 吉田成孝]
通讯作者: 吉田成孝
9
    Investigation for a New Mechanism of Demyelination in Demyelinating Model Mice
    • 批准号:
      24500404
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2012
    • 负责人:
      YOSHIDA Shigetaka
    • 依托单位:
    Elucidation of the role of Rac1 and MR in obese diabetic nephropathy and attempt at a novel therapeutic agent
    • 批准号:
      22790782
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      YOSHIDA Shigetaka
    • 依托单位:
    An Pedagogical Study of the Teaching Practices of the Learning Group Organized Diverse Children in Special Needs Education
    • 批准号:
      20730524
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.5万
    • 财政年份:
      2008
    • 负责人:
      YOSHIDA Shigetaka
    • 依托单位:
    The functions of proteases related to demyelination
    • 批准号:
      18500260
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.38万
    • 财政年份:
      2006
    • 负责人:
      YOSHIDA Shigetaka
    • 依托单位:
    海外基金