Effects of proteases on differentiation and maturation of oligodendrocytes
Effects of proteases on differentiation and maturation of oligodendrocytes
批准号:
21500322
负责人:
YOSHIDA Shigetaka
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
KLK6 is a serine protease specifically expressed in oligodendrocytes. The function of the protease on the maturation of oligodendrocyte has been undetermined. We analyzed KLK6 gene knockout (KLK6-KO) mice and found that the development of oligodendrocytes was temporally delayed. We also found that the expression of myelin basic protein was smaller in KLK6-KO mice than that of wild-type mice. These results indicate that KLK6 plays a role in the development of oligodendrocytes.
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Morphological changes of axons and myelin in experimental autoimmune encephalomyelitis
实验性自身免疫性脑脊髓炎轴突和髓磷脂的形态变化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[BandoY, Nomura T, Bochimoto H, Kouga D, Watanabe T, Yoshida S]
通讯作者:
Yoshida S
DOI:
10.1515/bc.2010.034
发表时间:
2010-04
期刊:
影响因子:
--
作者:
[S. Yoshida]
通讯作者:
S. Yoshida
KLK6ノックアウトマウスにおけるオリゴデンドロサイト関連マーカーの発現
KLK6敲除小鼠少突胶质细胞相关标志物的表达
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[村上公一, 板東良雄, 吉田成孝]
通讯作者:
吉田成孝
マウス多発性硬化症モデルにおけるKLK6を介した脱髄分子機所
KLK6介导的小鼠多发性硬化症模型脱髓鞘的分子机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[板東良雄, 村上公一, 吉田成孝]
通讯作者:
吉田成孝
オリゴデンドロサイトの生死とプロテアーゼ
少突胶质细胞和蛋白酶的生与死
DOI:
--
发表时间:
2010
期刊:
脳21
影响因子:
--
作者:
[Lee J, Kagamihara Y, Min K, Ishikawa T, Kakei S, 吉田成孝]
通讯作者:
吉田成孝
共 9 条
Investigation for a New Mechanism of Demyelination in Demyelinating Model Mice
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批准号:24500404
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2012
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负责人:YOSHIDA Shigetaka
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依托单位:
Elucidation of the role of Rac1 and MR in obese diabetic nephropathy and attempt at a novel therapeutic agent
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批准号:22790782
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:YOSHIDA Shigetaka
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依托单位:
An Pedagogical Study of the Teaching Practices of the Learning Group Organized Diverse Children in Special Needs Education
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批准号:20730524
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.5万
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财政年份:2008
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负责人:YOSHIDA Shigetaka
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依托单位:
The functions of proteases related to demyelination
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批准号:18500260
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.38万
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财政年份:2006
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负责人:YOSHIDA Shigetaka
-
依托单位:
Analysis of the functions of proteases related to demyelination
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批准号:16500212
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.86万
-
财政年份:2004
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负责人:YOSHIDA Shigetaka
-
依托单位:
Research on proteases related to demyelination expressed by oligodendrocytes
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批准号:13680830
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:2001
-
负责人:YOSHIDA Shigetaka
-
依托单位:
海外基金