A New Hypothesis on Brain Sexual Differentiation and Regulation of Hormone Sensitivity by Local Brain Estrogen-Synthesis

免疫组织化学结果显示，AR、ERα和ERβ在雌雄大鼠视前内侧核、杏仁核和海马区的表达具有性别差异，ERα免疫反应阳性细胞为海马区的SLH神经元。性别差异主要归因于雄激素上调AR，雌激素下调ERα，以及雌雄激素相对稳定的ERβ表达。提示HAP1/STB通过与AR、ERα、ERβ和GR的LBD结合，参与调节AR、ER、ER和GR的核转位。

Sexually dimorphic expression of AR, ERα, and ERβwere immunohistochemically clarified in the medial preoptic and amygdaloid nuclei and hippocampus of male and female rats ; ERα-immunoreactive cells were identified as the SLH neurons in the hippocampus. The sex differences were primarily attributable to up-regulation of AR by androgen, down-regulation of ERαby estrogen and relatively stable ERβexperession in both sexes. It was suggested that HAP1/ STB is involved in regulation of nuclear translocation of AR, ERα, ERβand GR through its binding to their LBDs in each cDNA-transfected cultured cells.