A New Hypothesis on Brain Sexual Differentiation and Regulation of Hormone Sensitivity by Local Brain Estrogen-Synthesis

关于大脑性别分化和局部大脑雌激素合成调节激素敏感性的新假设

• 批准号: 21500326
• 负责人: SHINODA Koh
• 金额: $ 2.75万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500326/
• 关键词: アンドロゲン受容体; エストロゲン受容体; HAP1; 内側視索前野; 分界条床核; 内側扁桃体; 海馬; アロマテース; stigmoid body; 脊髄小脳変性症

Sexually dimorphic expression of AR, ERα, and ERβwere immunohistochemically clarified in the medial preoptic and amygdaloid nuclei and hippocampus of male and female rats ; ERα-immunoreactive cells were identified as the SLH neurons in the hippocampus. The sex differences were primarily attributable to up-regulation of AR by androgen, down-regulation of ERαby estrogen and relatively stable ERβexperession in both sexes. It was suggested that HAP1/ STB is involved in regulation of nuclear translocation of AR, ERα, ERβand GR through its binding to their LBDs in each cDNA-transfected cultured cells.

免疫组化结果表明，雄性和雌性大鼠视前内侧核、杏仁核和海马中AR、ERα和ERβ的表达具有性别差异，ERα阳性细胞被鉴定为海马SLH神经元。这种性别差异主要归因于雄激素上调AR、雌激素下调ERα和ERβ相对稳定的表达。提示HAP 1/ STB可能通过与AR、ERα、ERβ和GR的LBD结合，参与调节AR、ERα、ERβ和GR核转位。

项目成果

斑点小体によるステロイド受容体のダイナミクス

斑点体类固醇受体的动力学

• 发表时间: 2011
• 作者: 岡達郎;横田茂文;津森登志子;牛建国;安井幸彦;森田晶子・宮田清司;篠田晃
• 通讯作者: 篠田晃

脳内エストロゲン合成と脳の性差形成

大脑中雌激素的合成以及大脑中性别差异的形成

• 发表时间: 2011
• 作者: Shibata S;Yasuda A;Renault-Mihara F;Suyama S;Katoh H;Inoue T;Inoue;YU;Nagoshi N;Sato M;Nakamura M;Akazawa C;Okano H.;森田晶子・中島敏博・宮田清司;神野尚三;篠田晃
• 通讯作者: 篠田晃

物忘れと認知症

健忘和痴呆

• 发表时间: 2011
• 作者: Watanabe-Hosomi A;Watanabe Y;Tanaka M;Nakagawa M;Mizuno T;篠田晃
• 通讯作者: 篠田晃

Relaying function of the STB/ HAP1 on nuclear translocation of androgen and glucocorticoid receptors and its proteasome-dependent regulation. Neuro2010

STB/HAP1 对雄激素和糖皮质激素受体核转位的中继功能及其蛋白酶体依赖性调节。

• 发表时间: 2010
• 作者: Ryutaro Fujinaga;Yukio Takeshita;Kazuhiro Yoshioka;Hiroyuki Nakamura;Shuhei Shinoda;Akie Yanai;Keiji Kokubu;Koh Shinoda
• 通讯作者: Koh Shinoda

Intracellular colocalization of HAP1/STBs with steroid hormone receptors and its enhancement by a proteasome inhibitor

• DOI: 10.1016/j.yexcr.2011.05.004
• 发表时间: 2011-07-15
• 期刊: EXPERIMENTAL CELL RESEARCH
• 影响因子: 3.7
• 作者: Fujinaga, Ryutaro;Takeshita, Yukio;Shinoda, Koh
• 通讯作者: Shinoda, Koh