A New Hypothesis on Brain Sexual Differentiation and Regulation of Hormone Sensitivity by Local Brain Estrogen-Synthesis

免疫组化结果表明，雄性和雌性大鼠视前内侧核、杏仁核和海马中AR、ERα和ERβ的表达具有性别差异，ERα阳性细胞被鉴定为海马SLH神经元。这种性别差异主要归因于雄激素上调AR、雌激素下调ERα和ERβ相对稳定的表达。提示HAP 1/ STB可能通过与AR、ERα、ERβ和GR的LBD结合，参与调节AR、ERα、ERβ和GR核转位。

Sexually dimorphic expression of AR, ERα, and ERβwere immunohistochemically clarified in the medial preoptic and amygdaloid nuclei and hippocampus of male and female rats ; ERα-immunoreactive cells were identified as the SLH neurons in the hippocampus. The sex differences were primarily attributable to up-regulation of AR by androgen, down-regulation of ERαby estrogen and relatively stable ERβexperession in both sexes. It was suggested that HAP1/ STB is involved in regulation of nuclear translocation of AR, ERα, ERβand GR through its binding to their LBDs in each cDNA-transfected cultured cells.